Alzheimer's Disease and Frontotemporal Dementias

A Review with Particular Reference to Pin1 Protein

 

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Compiled by: Julian Thorpe

 

Pick's Disease (PiD)

N.B. This page is in the initial phases of construction, so I suggest you follow the external link below for more on this disease.

(external site links in italics )

See:   NINDS Pick's disease Information Page and the 'Institut National de la Sante et de la Recherche Medical' website for more detail on PiD.
Type: PiD is a sporadic tauopathy belonging to the frontotemporal dementia (FTD) group of neurodegenerative diseases. 
Regions affected:  neocortex and hippocampus.
Tau pathology: Neuronal:  Pick bodies of straight and twisted filaments of tau in the neocortex (most numerous in layers 2 and 6) and in the dentate granule neurons of the hippocampus. Glial :  
Other Pathology: frontotemporal lobar and limbic atrophy, spongiosis and gliosis.

Some Related References

Arai, T, Ikeda, K, Akiyama, H, Shikamoto, Y, Tsuchiya, K, Yagishita, S, Beach, T, Rogers, J, Schwab, C, McGeer, PL (2001) Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy. ACTA NEUROPATHOLOGICA 101: 167-173

Arai, T, Ikeda, K, Akiyama, H, Tsuchiya, K, Iritani, S, Ishiguro, K, Yagishita, S, Oda, T, Odawara, T, Iseki, E (2003) Different immunoreactivities of the microtubule-binding region of tau and its molecular basis in brains from patients with Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. ACTA NEUROPATHOLOGICA 105: 489-498

Arai, T, Nonaka, T, Hasegawa, M, Akiyama, H, Yoshida, M, Hashizume, Y, Tsuchiya, K, Oda, T, Ikeda, K (2003) Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62. NEUROSCIENCE LETTERS 342: 41-44

Armstrong_RA, Cairns_NJ, Lantos_PL (1999)  Laminar distribution of Pick bodies, Pick cells and Alzheimer disease pathology in the frontal and temporal cortex in Pick's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 25: 266-271

Bird, T, Knopman, D, VanSwieten, J, Rosso, S, Feldman, H, Tanabe, H, Graff-Raford, N, Geschwind, D, Verpillat, P, Hutton, M (2003) Epidemiology and genetics of frontotemporal dementia/Pick's disease. ANNALS OF NEUROLOGY 54: S29-S31

de Brito-Marques, PR, de Mello, RV, Montenegro, L (2001) Classic Pick's disease type with ubiquitin-positive and tau-negative inclusions - Case report. ARQUIVOS DE NEURO-PSIQUIATRIA 59: 128-133

Dickson, DW (2001) Neuropathology of Pick's disease. NEUROLOGY 56: S16-S20

Ferrer, I (2002) Differential expression of phosphorylated translation initiation factor 2 alpha in Alzheimer's disease and Creutzfeldt-Jakob's disease . NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 28: 441-451

Ferrer, I, Barrachina, M, Puig, B (2002) Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration . ACTA NEUROPATHOLOGICA 104: 583-591

Ferrer, I, Barrachina, M, Puig, B (2002) Anti-tau phospho-specific Ser(262) antibody recognizes a variety of abnormal hyperphosphorylated tau deposits in tauopathies including Pick bodies and argyrophilic grains . ACTA NEUROPATHOLOGICA 104: 658-664

Ferrer, I, Barrachina, M, Tolnay, M, Rey, MJ, Vidal, N, Carmona, M, Blanco, R, Puig, B (2003) Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease. BRAIN PATHOLOGY 13: 62-78

Ferrer, I, Blanco, R, Carmona, M, Ribera, R, Goutan, E, Puig, B, Rey, MJ, Cardozo, A, Vinals, F and Ribalta, T (2001) Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. BRAIN PATHOLOGY 11: 144-158

Hartzler, AW, Zhu, XW, Siedlak, SL, Castellani, RJ, Avila, J, Perry, G, Smith, MA (2002) The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau . NEUROBIOLOGY OF AGING 23: 855-859

Ikeda, K, Akiyama, H, Arai, T, Tsuchiya, K (2002) Pick-body-like inclusions in corticobasal degeneration differ from Pick bodies in Pick's disease. ACTA NEUROPATHOLOGICA 103: 115-118

Ikeda, K, Akiyama, H, Arai, T, Ueno, H, Tsuchiya, K, Kosaka, K (2002) Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia. ACTA NEUROPATHOLOGICA 104: 21-28

Kertesz, A (2003) Pick complex: An integrative approach to frontotemporal dementia - Primary progressive aphasia, corticobasal degeneration, and progressive supranuclear palsy. NEUROLOGIST 9: 311-317

Kertesz, A, Munoz, DG (2003) Primary progressive aphasia and Pick complex. JOURNAL OF THE NEUROLOGICAL SCIENCES 206: 97-107

Kikuchi, K, Arawaka, S, Koyama, S, Kimura, H, Ren, CH, Wada, M, Kawanami, T, Kurita, K, Daimon, M, Kawakatsu, S, Kadoya, T, Goto, K, Kato, T (2003) An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 308: 646-654

King, ME, Ghoshal, N, Wall, JS, Binder, LI and Ksiezak-Reding, H (2001) Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments. AMERICAN JOURNAL OF PATHOLOGY 158: 1481-1490

Lee, VMY, Trojanowski, JQ (2001) Transgenic mouse models of tauopathies: Prospects for animal models of Pick's disease. NEUROLOGY 56: S26-S30

Mori, F, Hayashi, S, Yamagishi, S, Yoshimoto, M, Yagihashi, S, Takahashi, H, Wakabayashi, K (2002) Pick's disease: alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus. ACTA NEUROPATHOLOGICA 104: 455-461

Morris, HR, Baker, M, Yasojima, K, Houlden, H, Khan, MN, Wood, NW, Hardy, J, Grossman, M, Trojanowski, J, Revesz, T, Bigio, EH, Bergeron, C, Janssen, JC, McGeer, PL, Rossor, MN, Lees, AJ, Lantos, PL, Hutton, M (2002) Analysis of tau haplotypes in Pick's disease. NEUROLOGY 59: 443-445

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Neumann, M, Muller, V, Gorner, K, Kretzschmar, HA, Haass, C, Kahle, PJ (2004) Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. ACTA NEUROPATHOLOGICA 107: 489-496

Neumann, M, Schulz-Schaeffer, W, Crowther, RA, Smith, MJ, Spillantini, MG, Goedert, M, Kretzschmar, HA (2001) Pick's disease associated with the novel Tau gene mutation K369I. ANNALS OF NEUROLOGY 50: 503-513

Odawara, T, Iseki, E, Kanai, A, Arai, T, Katsuragi, T, Hino, H, Furukawa, Y, Kato, M, Yamamoto, T, Kosaka, K (2003) Clinicopathological study of two subtypes of Pick's disease in Japan. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 15: 19-25

Odawara, T, Shiozaki, K, Iseki, E, Hino, H, Kosaka, K (2003) Alterations of muscarinic acetylcholine receptors in atypical Pick's disease without Pick bodies. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 74: 965-967  

Pollak, D, Cairns, N, Lubec, G (2003) Cytoskeleton derangement in brain of patients with Down Syndrome, Alzheimer's disease and Pick's disease. JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT 67: 149-158

Probst, A, Herzig, MC, Mistl, C, Ipsen, S, Tolnay, M (2001) Perisomatic granules (non-plaque dystrophic dendrites) of hippocampal CA1 neurons in Alzheimer's disease and Pick's disease: a lesion distinct from granulovacuolar degeneration. ACTA NEUROPATHOLOGICA 102: 636-644

Rademakers, R, Cruts, M, van Broeckhoven, C (2004) The role of tau (MAPT) in frontotemporal dementia and related tauopathies. HUMAN MUTATION 24: 277-295

Rosso, SM, van Herpen, E, Deelen, W, Kamphorst, W, Severijnen, LA, Willemsen, R, Ravid, R, Niermeijer, MF, Dooijes, D, Smith, MJ, Goedert, M, Heutink, P, van Swieten, JC (2002) A novel tau mutation, S320F, causes a Tauopathy with inclusions similar to those in Pick's disease. ANNALS OF NEUROLOGY 51: 373-376

Russ, C, Lovestone, S, Baker, M, Pickering-Brown, SM, Andersen, PM, Furlong, R, Mann, D, Powell, JF (2001) The extended haplotype of the microtubule associated protein tau gene is not associated with Pick's disease. NEUROSCIENCE LETTERS 299: 156-158

Schofield, E, Kersaitis, C, Shepherd, CE, Kril, JJ, Halliday, GM (2003) Severity of gliosis in Pick's disease and frontotemporal lobar degeneration: tau-positive glia differentiate these disorders. BRAIN 126: 827-840

Sobrido, MJ, Abu-Khalil, A, Weintraub, S, Johnson, N, Quinn, B, Cummings, JL, Mesulam, MM, Geschwind, DH (2003) Possible association of the tau H1/H1 genotype with primary progressive aphasia. NEUROLOGY 60: 862-864

Tsuchiya, K, Ikeda, K (2002) Basal ganglia lesions in 'Pick complex': A topographic neuropathological study of 19 autopsy cases. NEUROPATHOLOGY 22: 323-336

Tsuchiya, K, Ikeda, M, Hasegawa, K, Fukui, T, Kuroiwa, T, Haga, C, Oyanagi, S, Nakano, I, Matsushita, M, Yagishita, S, Ikeda, K (2001) Distribution of cerebral cortical lesions in Pick's disease with Pick bodies: a clinicopathological study of six autopsy cases showing unusual clinical presentations. ACTA NEUROPATHOLOGICA 102: 553-571

Tsuchiya, K, Ishizu, H, Nakano, I, Kita, Y, Sawabe, M, Haga, C, Kuyama, K, Nishinaka, T, Oyanagi, K, Ikeda, K, Kuroda, S (2001) Distribution of basal ganglia lesions in generalized variant of Pick's disease: a clinicopathological study of four autopsy cases. ACTA NEUROPATHOLOGICA 102: 441-448

Uchihara, T, Ikeda, K, Tsuchiya, K (2003) Pick body disease and Pick syndrome. NEUROPATHOLOGY 23: 318-326

Yokota, O, Ishizu, H, Terada, S, Tsuchiya, K, Haraguchi, T, Nose, S, Kawai, K, Ikeda, K, Kuroda, S (2002) Preservation of nigral neurons in Pick's disease with Pick bodies: a clinicopathological and morphometric study of five autopsy cases. JOURNAL OF THE NEUROLOGICAL SCIENCES 194: 41-48

Zhukareva, V, Mann, D, Pickering-Brown, S, Uryu, K, Shuck, T, Shah, K, Grossman, M, Miller, BL, Hulette, CM, Feinstein, SC, Trojanowski, JQ, Lee, VMY (2002) Sporadic Pick's disease: A tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter. ANNALS OF NEUROLOGY 51: 730-739

Zhukareva, V, Shah, K, Uryu, K, Braak, H, Del Tredici, K, Sundarraj, S, Clark, C, Trojanowski, JQ, Lee, VMY (2002) Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease - A  comparative study . AMERICAN JOURNAL OF PATHOLOGY 161: 1135-1141

Zhukareva, V, Sundarraj, S, Mann, D, Sjogren, M, Blenow, K, Clark, CM, McKeel, DW, Goate, A, Lippa, CF, Vonsattel, JP, Growdon, JH, Trojanowski, JQ, Lee, VMY (2003) Selective reduction of soluble Tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study. ACTA NEUROPATHOLOGICA 105: 469-476

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