Literature: A-K ; L-Z ; subject area
Compiled by: Julian Thorpe
Apoptosis
|
Please Note: Due to time constraints, the text part of this page has not been updated for some time. However, references are added reasonably frequently. |
 | As Czech et al. (2000) have recently stated
in their review article: ".....several lines of evidence support
a role of apoptosis in the massive neuronal loss observed (inAD)
."E.g., see Anderson et al. (2000)and
other references
. |
| Yuan and Yankner (2000) report in
Nature that neuronal apoptosis has a potentially important
role in neurodegenerative diseases (as well as an involvement in the
'sculpturing' of the developing brain). They suggest that the precise
elucidation of such neuronal cell death might provide additional points
for therapeutic interventions. |
| While there is no doubt that death is the ultimate
fate of at least a significant proportion of AD-affected
neurons, there is still much debate about the nature of this death. There
are those (del Rio and Velez-Pardo, 2001) who dispute that the
involvement of apoptosis in AD has been truly confirmed, as the more terminal
phases, such as chromatin condensation, apoptotic bodies, and blebbing,
are rarely (except e.g. Su et al., 1994) seen in AD. However,
most researchers appear to agree that some sort of apoptosis occurs,
albeit, perhaps, in a different form from that occurring in normal tissues. |
| Although there is apparent consensus that some
form of apoptosis takes place, the latter is but one of an
increasing number of programmed cell death (PCD) mechanisms that can occur
in cells and that may be triggered concurrently. These latter have recently
been reviewed (Leist and Jäättelä, 2001) ) with
the conclusion that, specifically in regard to neurons, there appear to
be extra controls for caspase activation and that caspase-independent death
pathways may be preferentially-activated. |
| The
stimulation of mitotic events
in AD-affected neurons may well contribute to this
apoptosis (e.g. see Mattson, 2000; Offen et al., 2000;
Yuan and Yankner, 2000). |
| Pin1's possible involvements in neuronal apoptosis |
:
http://www.freemedicaljournals.com/
(These journals include: Neurology,
Neurobiology of Disease, Journal of Neurochemistry, Alzheimer's
Disease Review)
Abramova, NA, Cassarino, DS, Khan, SM, Painter, TW, Bennett, JP (2002) Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma. JOURNAL OF NEUROSCIENCE RESEARCH 67: 494-500
Allen, JW, Eldadah, BA, Huang, XL, Knoblach, SM and Faden, AI (2001) Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis. JOURNAL OF NEUROSCIENCE RESEARCH 65: 45-53
Anderson, AJ, Stoltzner, S, Lai, F, Su, J and Nixon, RA (2000) Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL. NEUROBIOLOGY OF AGING 21: 511-524
Anderson, AJ, Su, JH and Cotman, CW (1996) DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. JOURNAL OF NEUROSCIENCE 16: 1710-1719
Andersson, K, Olofsson, A, Nielsen, EH, Svehag, SE, Lundgren, E (2002) Only amyloidogenic intermediates of transthyretin induce apoptosis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 294: 309-314
Andorfer, C, Acker, CM, Kress, Y, Hof, PR, Duff, K, Davies, P (2005) Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. JOURNAL OF NEUROSCIENCE 25: 5446-5454
Araki, W, Yuasa, K, Takeda, S, Shirotani, K, Takahashi, K, Tabira, T (2000) Overexpression of presenilin-2 enhances apoptotic death of cultured cortical neurons. MOLECULAR BASIS OF DEMENTIA. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 920: 241-244
Araki, W, Yuasa, K, Takeda, S, Takeda, K, Shirotani, K, Takahashi, K, Tabira, T (2001) Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons. JOURNAL OF NEUROCHEMISTRY 79: 1161-1168
Arendt, T, Holzer, M, Stobe, A, Gartner, U, Luth, HJ, Bruckner, MK, Ueberham, U (2000) Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer's disease that eventually results in cell death. MOLECULAR BASIS OF DEMENTIA. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 920: 249-255
Atzori, C, Ghetti, B, Piva, R, Srinivasan, AN, Zolo, P, Delisle, MB, Mirra, SS, Migheli, A (2001) Activation of the JNK/p38 pathway occurs in diseases characterized by tau protein pathology and is related to tau phosphorylation but not to apoptosis. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 60: 1190-1197
Bamberger, ME, Landreth, GE (2002) Inflammation, apoptosis, and Alzheimer's disease. NEUROSCIENTIST 8: 276-283
Bao, L, Kimzey, A, Sauter, G, Sowadski, JM, Lu, KP, Wang, DG (2004) Prevalent overexpression of prolyl isomerase Pin1 in human cancers. AMERICAN JOURNAL OF PATHOLOGY 164: 1727-1737
Basu, A, Haldar, S (2002) Signal-induced site specific phosphorylation targets Bcl2 to the proteasome pathway. INTERNATIONAL JOURNAL OF ONCOLOGY 21: 597-601
Basu,
A, Das, M, Qanungo, S, Fan, CJ, DuBois, G, Haldar, S (2002)
Proteasomal degradation of human peptidyl prolyl
isomerase Pin1-pointing phospho Bcl2 toward dephosphorylation. NEOPLASIA 4: 218-227
Bertrand, E, Brouillet, E, Caille, I, Bouillot, C, Cole, GM, Prochiantz, A, Allinquant, B (2001) A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo. MOLECULAR AND CELLULAR NEUROSCIENCE 18: 503-511
Bishop, GM, Robinson, SR (2003) Deposits of fibrillar A beta do not cause neuronal loss or ferritin expression in adult rat brain. JOURNAL OF NEURAL TRANSMISSION 110: 381-400
Blasko, I, Wagner, M, Whitaker, N, Grubeck-Loebenstein, B and Jansen-Durr, P (2000) The amyloid beta peptide A beta (25-35) induces apoptosis independent of p53. FEBS LETTERS 470: 221-225
Boldyrev, A, Koudinov, A, Berezov, T, Carpenter, DO (2004) Amyloid-beta induced cell death is independent of free radicals. JOURNAL OF ALZHEIMERS DISEASE 6: 633-638
Bondolfi, L, Calhoun, M, Ermini, F, Kuhn, HG, Wiederhold, KH, Walker, L, Staufenbiel, M, Jucker, M (2002) Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice. JOURNAL OF NEUROSCIENCE 22: 515-522
Bozyczko-Coyne, D, O'Kane, TM, Wu, ZL, Dobrzanski, P, Murthy, S, Vaught, JL and Scott, RW (2001) CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with A beta-induced cortical neuron apoptosis. JOURNAL OF NEUROCHEMISTRY 77: 849-863
Bree, RT, Neary, C, Samali, A, Lowndes, NF (2004) The switch from survival responses to apoptosis after chromosomal breaks. DNA REPAIR 3: 989-995
Broe, M, Shepherd, CE, Milward, EA and Halliday, GM (2001) Relationship between DNA fragmentation, morphological changes and neuronal loss in Alzheimer's disease and dementia with Lewy bodies. ACTA NEUROPATHOLOGICA 101: 616-624
Bulavin, DV, Fornace, AJ (2004) p38 MAP kinase's emerging role as a tumor suppressor. ADVANCES IN CANCER RESEARCH 92: 95-118
Bulavin, DV, Kovalsky, O, Hollander, MC, Fornace, AJ (2003) Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of gadd45a. MOLECULAR AND CELLULAR BIOLOGY 23: 3859-3871
Busser, J, Geldmacher, DS and Herrup, K (1998) Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. JOURNAL OF NEUROSCIENCE 18: 2801-2807
Cardoso, SM, Swerdlow, RH, Oliveira, CR (2002) Induction of cytochrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria. BRAIN RESEARCH 931: 117-125
Chang, NS, Doherty, J, Ensign, A, Lewis, J, Heath, J,
Schultz, L, Chen, ST, Oppermann, U (2003)
Molecular mechanisms underlying WOX1 activation during apoptotic and stress
responses. BIOCHEMICAL PHARMACOLOGY 66: 1347-1354
Chang, RCC, Wong, AKY, Ng, HK,
Hugon, J (2002) Phosphorylation of eukaryotic
initiation factor-2 alpha (eIF2 alpha) is associated with neuronal degeneration
in Alzheimer's disease. NEUROREPORT 13: 2429-2432
Chen, YZ (2004) APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin. APOPTOSIS 9: 415-422
Chen, YZ, Liu, WY, McPhie, DL, Hassinger, L, Neve, RL
(2003) APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is
increased in Alzheimer's disease brain. JOURNAL OF CELL BIOLOGY 163: 27-33
Chen, YZ, McPhie, DL, Hirschberg, J and Neve, RL (2000) The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. JOURNAL OF BIOLOGICAL CHEMISTRY 275: 8929-8935
Cheung, ZH, Ip, NY (2004) Cdk5: mediator of neuronal death and survival. NEUROSCIENCE LETTERS 361: 47-51
Chung, YH, Shin, CM, Kim, MJ, Lee, BK, Park, KH and Cha, CI (2000) Immunocytochemical study on the distribution of p53 in the hippocampus and cerebellum of the aged rat. BRAIN RESEARCH 885: 137-141
Chung, CW, Song, YH, Kim, IK, Yoon, WJ, Ryu, BR, Jo, DG, Woo, HN, Kwon, YK, Kim, HH, Gwag, BJ, Mook-Jung, IH and Jung, YK (2001) Proapoptotic effects of Tau cleavage product generated by caspase-3. NEUROBIOLOGY OF DISEASE 8: 162-172
Colangelo, V, Schurr, J, Ball, MJ, Pelaez, RP, Bazan,
NG, Lukiw, WJ (2002) Gene expression profiling of 12633 genes in Alzheimer
hippocampal CA1: Transcription and neurotrophic factor down-regulation and
up-regulation of apoptotic and pro-inflammatory signaling
Colurso, GJ, Nilson, JE, Vervoort, LG (2003)
Quantitative assessment of DNA fragmentation and beta-amyloid deposition in
insular cortex and midfrontal gyrus from patients with Alzheimer's disease. LIFE
SCIENCES 73: 1795-1803
Combs, CK, Karlo, JC, Kao, SC and Landreth, GE (2001) beta-Amyloid stimulation of microglia and monocytes results in TNF alpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. JOURNAL OF NEUROSCIENCE 21: 1179-1188
Copani, A, Condorelli, F, Caruso, A, Vancheri, C, Sala, A, Stella, AMG, Canonico, PL, Nicoletti, F and Sortino, MA (1999) Mitotic signaling by beta-amyloid causes neuronal death. FASEB JOURNAL 13: 2225-2234
Copani, A, Melchiorri, D, Caricasole, A, Martini, F, Sale, P, Carnevale, R, Gradini, R, Sortino, MA, Lenti, L, De Maria, R, Nicoletti, F (2002) beta-amyloid-induced synthesis of the ganglioside Gd3 is a requisite for cell cycle reactivation and apoptosis in neurons. JOURNAL OF NEUROSCIENCE 22: 3963-3968
Cotman, CW, Poon, WW, Rissman, RA, Blurton-Jones, M (2005) The role of caspase cleavage of tau in Alzheimer disease neuropathology. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 64: 104-112
Culmsee, C, Zhu, XX, Yu, QS, Chan, SL, Camandola, S, Guo, ZH, Greig, NH and Mattson, MP (2001) A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. JOURNAL OF NEUROCHEMISTRY 77: 220-228
da Costa, CA, Mattson, MP, Ancolio, K, Checler, F
(2003) The C-terminal fragment of presenilin 2 triggers p53-mediated
staurosporine-induced apoptosis, a function independent of the presenilinase-derived
N-terminal counterpart. JOURNAL OF BIOLOGICAL CHEMISTRY 278: 12064-12069
da Costa, CA, Paitel, E, Mattson, MP, Amson, R, Telerman, A, Ancolio,
K, Checler, F (2002) Wild-type and mutated presenilins
2 trigger p53-dependent apoptosis and down-regulate presenilin
1 expression in HEK293 human cells and in murine neurons. PROCEEDINGS
OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
99: 4043-4048
Daniel, PT (2000) Dissecting the pathways to death. LEUKEMIA 14: 2035-2044
De la Monte, SM and Wands, JR (2001) Alzheimer-Associated neuronal thread protein-induced apoptosis and impaired mitochondrial function in human central nervous system-derived neuronal cells. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 60: 195-207
Del Rio, MJ, Velez-Pardo, C (2002) Monoamine neurotoxins-induced
apoptosis in lymphocytes by a common oxidative stress mechanism:
involvement of hydrogen peroxide (H2O2), caspase-3, and nuclear
factor kappa-B (NF-kappa B), p53, c-Jun transcription factors.
BIOCHEMICAL PHARMACOLOGY 63: 677-688
del Rio, MJ and Velez-Pardo, C (2001) Apoptosis in neurodegenerative diseases: Facts and controversies. REVISTA DE NEUROLOGIA 32: 851-86
Demeester, N, Baier, G, Enzinger, C, Goethals, M, Vandekerckhove, J, Rosseneu, M and Labeur, C (2001) Apoptosis induced in neuronal cells by C-terminal amyloid beta-fragments is correlated with their aggregation properties in phospholipid membranes. MOLECULAR MEMBRANE BIOLOGY 17: 219-228
De Vrij, FMS, Sluijs, JA, Gregori, L, Fischer, DF, Hermens, WTJMC, Goldgaber, D, Verhaagen, J, Van Leeuwen, FW, Hol, EM (2001) Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death. FASEB JOURNAL 15: 2680-2688
Dispersyn, G, Nuydens, R, Connors, R, Borgers, M and Geerts, H (1999)
Bcl-2 protects against FCCP-induced
apoptosis and mitochondrial membrane potential depolarization
in PC12 cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL
SUBJECTS 1428: 357-371
Ditaranto-Desimone, K, Saito, M, Tekirian, TL, Saito, M, Berg, M, Dubowchik, G, Soreghan, B, Thomas, S, Marks, N, Yang, AJ (2003) Neuronal endosomal/lysosomal membrane destabilization activates caspases and induces abnormal accumulation of the lipid secondary messenger ceramide. BRAIN RESEARCH BULLETIN 59: 523-531
Dumanchin-Njock, C, da Costa, CA, Mercken, L, Pradier, L and Checler, F (2001) The caspase-derived C-terminal fragment of beta APP induces caspase-independent toxicity and triggers selective increase of A beta 42 in mammalian cells. JOURNAL OF NEUROCHEMISTRY 78: 1153-1161
Eckert, A, Marques, CA, Keil, U, Schussel, K, Muller, WE (2004) Increased apoptotic cell death in sporadic and genetic Alzheimer's disease. APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1010: 604-609
Eckert, A, Oster, M, Zerfass, R, Hennerici, M and Muller, WE (2001) Elevated levels of fragmented DNA nucleosomes in native and activated lymphocytes indicate an enhanced sensitivity to apoptosis in sporadic Alzheimer's disease - Specific differences to vascular dementia. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 12: 98-105
Eckert, A, Steiner, B, Marques, C, Leutz, S, Romig, H, Haass, C and Muller, WE (2001) Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation. JOURNAL OF NEUROSCIENCE RESEARCH 64: 183-192
Eldadah, BA and Faden, AI (2000) Caspase pathways, neuronal apoptosis, and CNS injury. JOURNAL OF NEUROTRAUMA 17: 811-829
El-Guendy, N, Rangnekar, VM (2003) Apoptosis by Par-4 in cancer and neurodegenerative
diseases
Engidawork, E, Gulesserian, T, Yoo, BC, Cairns, N and Lubec, G (2001) Alteration of Caspases and Apoptosis-Related Proteins in Brains of Patients with Alzheimer's Disease. Biochem. Biophys. Res. Comm. 281: 84-93
Ethell, DW, Buhler, L (2003) Fas ligand-mediated apoptosis in degenerative disorders of the brain. JOURNAL OF CLINICAL IMMUNOLOGY 23: 439-446
Feinstein, SC, Wilson, L (2005) Inability of tau to properly regulate neuronal microtubule dynamics: a loss-of-function mechanism by which tau might mediate neuronal cell death. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739: 268-279
Ferrer, I, Blanco, R, Carmona, M, Ribera, R, Goutan, E, Puig, B, Rey, MJ, Cardozo, A, Vinals, F and Ribalta, T (2001) Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration. BRAIN PATHOLOGY 11: 144-158
Garcia-Ospina, GP, Jimenez-Del Rio, M, Lopera, F,
Velez-Pardo, C (2003) Neuronal DNA damage correlates with a positive
detection of c-Jun nuclear factor kappa B, p53 and Par-4 transcription factors
in Alzheimer's disease. REVISTA DE NEUROLOGIA 36: 1004-1010
Gary, DS and Mattson, MP (2001) Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis. JOURNAL OF NEUROCHEMISTRY 76: 1485-1496
Ghribi, O, DeWitt, DA, Forbes, MS, Herman, MM and Savory, J (2001) Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits. BRAIN RESEARCH 903: 66-73
Giffard, RG, Xu, LJ, Heng, Z, Carrico, W, Ouyang, YB, Qiao, YL, Sapolsky, R, Steinberg, G, Hu, BR, Yenari, MA (2004) Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury. JOURNAL OF EXPERIMENTAL BIOLOGY 207: 3213-3220
Giovanni, A, Keramaris, E, Morris, EJ, Hou, ST, O'Hare, M, Dyson, N, Robertson, GS, Slack, RS and Park, DS (2000) E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3. JOURNAL OF BIOLOGICAL CHEMISTRY 275: 11553-11560
Giovanni, A, Wirtz-Brugger, F, Keramaris, E, Slack, R and Park, DS (1999) Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F center dot DP, in B-amyloid-induced neuronal death. JOURNAL OF BIOLOGICAL CHEMISTRY 274: 19011-19016
Gostissa, M, Hofmann, TG, Will, H, Del Sal, G (2003)
Regulation of p53 functions: let's meet at the nuclear bodies. CURRENT OPINION
IN CELL BIOLOGY 15: 351-357
Guise, S, Braguer, D, Carles, G, Delacourte, A and Briand, C (2001) Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells. JOURNAL OF NEUROSCIENCE RESEARCH 63: 257-267
Guo, GW and Liang, YX (2001) Aluminum-induced apoptosis in cultured astrocytes and its effect on calcium homeostasis. BRAIN RESEARCH 888: 221-226
Hamdane, M, Delobel, P, Sambo, AV, Smet, C, Begard, S,
Violleau, A, Landrieu, I, Delacourte, A, Lippens, G, Flament, S, Buee, L (2003)
Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to
neuronal apoptosis? BIOCHEMICAL PHARMACOLOGY 66: 1619-1625
Hashimoto, Y, Tsuji, O, Niikura, T, Yamagishi, Y, Ishizaka, M, Kawasumi, M, Chiba, T, Kanekura, K, Yamada, M, Tsukamoto, E, Kouyama, K, Terashita, K, Aiso, S, Lin, A, Nishimoto, I (2003) Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death. JOURNAL OF NEUROCHEMISTRY 84: 864-877
Hashimoto, Y, Jiang, H, Niikura, T, Ito, Y, Hagiwara, A, Umezawa, K, Abe, Y, Murayama, Y and Nishimoto, I (2000) Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases. JOURNAL OF NEUROSCIENCE 20: 8401-8409
Head, E, Lott, IT, Cribbs, DH, Cotman, CW, Rohn, TT
(2002) beta-amyloid deposition and neurofibrillary tangle
association with caspase activation in Down syndrome
Heese, K, Nagai, Y, Sawada, T (2003) Comparative gene identification-94 - A pivotal regulator of apoptosis. NEUROSCIENCE 116: 321-324
Helbecque, N, Abderrhamani, A, Meylan, L, Riederer, B,
Mooser, V, Miklossy, J, Delplanque, J, Boutin, P, Nicod, P, Haefliger, JA,
Cottel, D, Amouyel, P, Froguel, P, Waeber, G (2003)
Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter
variant is associated with Alzheimer's disease. MOLECULAR PSYCHIATRY 8: 413-422
Herrup, K, Neve, R, Ackerman, SL, Copani, A (2004) Divide and die: Cell cycle events as triggers of nerve cell death. JOURNAL OF NEUROSCIENCE 24: 9232-9239
Hershko, T, Chaussepied, M, Oren, M, Ginsberg, D (2005) Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. CELL DEATH AND DIFFERENTIATION 12: 377-383
Hitomi, J, Katayama, T, Eguchi, Y, Kudo, T, Taniguchi, M, Koyama, Y, Manabe, T, Yamagishi, S, Bando, Y, Imaizumi, K, Tsujimoto, Y, Tohyama, M (2004) Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and A beta-induced cell death. JOURNAL OF CELL BIOLOGY 165: 347-356
Ishimaru, D, Andrade, LR, Teixeira, LSP, Quesado, PA,
Maiolino, LM, Lopez, PM, Cordeiro, Y, Costa, LT, Heckl, WM, Weissmuller, G,
Foguel, D, Silva, JL (2003) Fibrillar aggregates of the tumor suppressor p53
core domain. BIOCHEMISTRY 42: 9022-9027
Jang, JH, Surh, YJ (2002) beta-amyloid induces oxidative DNA damage and cell
death through activation of c-Jun N terminal kinase
Jellinger, KA (2001) Cell death mechanisms in neurodegeneration. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 5: 1-17
Jo, DG, Chang, JW, Hong, HS, Mook-Jung, I, Jung, YK
(2003) Contribution of presenilin/gamma-secretase to calsenilin-mediated
apoptosis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 305: 62-66
Jordan, J, Cena, V, Prehn, JHM (2003) Mitochondrial control of neuron death and its role in neurodegenerative disorders. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY 59: 129-141
Kajkowski, EM, Lo, CF, Ning, XP, Walker, S, Sofia, HJ, Wang, W, Edris, W, Chanda, P, Wagner, E, Vile, S, Ryan, K, McHendry-Rinde, B, Smith, SC, Wood, A, Rhodes, KJ, Kennedy, JD, Bard, J, Jacobsen, JS and Ozenberger, BA (2001) beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module. JOURNAL OF BIOLOGICAL CHEMISTRY 276: 18748-18756
Kang, HJ, Yoon, WJ, Moon, GJ, Kim, DY, Sohn, S, Kwon, HJ, Gwag, BJ (2005) Caspase-3-mediated cleavage of PHF-1 tau during apoptosis irrespective of excitotoxicity and oxidative stress: an implication to Alzheimer's disease. NEUROBIOLOGY OF DISEASE 18: 450-458
Kato, S, Han, SY, Liu, W, Otsuka, K, Shibata, H, Kanamaru, R, Ishioka, C (2003) Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 100: 8424-8429
Kemppainen, N, Roytta, M, Collan, Y, Ma, SY, Hinkka, S, Rinne, JO (2002) Unbiased morphological measurements show no neuronal loss in the substantia nigra in Alzheimer's disease. ACTA NEUROPATHOLOGICA 103: 43-47
Kerokoski, P, Suuronen, T, Salminen, A, Soininen, H and Pirttilä, T (2001) The Levels of cdk5 and p35 Proteins and Tau Phosphorylation Are Reduced during Neuronal Apoptosis. Biochem. Biophys. Res. Comm. 280: 998-1002
Kienlen-Campard, P, Miolet, S, Tasiaux, B, Octave, JN (2002) Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY 277: 15666-15670
Kikuchi, S, Shinpo, K, Takeuchi, M, Yamagishi, S,
Makita, Z, Sasaki, N, Tashiro, K (2003)
Glycation - a sweet tempter for neuronal death. BRAIN RESEARCH REVIEWS 41:
306-323
Kim, HS, Lee, JH, Lee, JP, Kim, EM, Chang, KA, Park,
CH, Jeong, SJ, Wittendorp, MC, Seo, JH, Choi,
SH, Suh, YH (2002) Amyloid beta peptide induces cytochrome c release from
isolated mitochondria
Kingham, PJ and Pocock, JM (2001) Microglial secreted cathepsin B induces neuronal apoptosis. JOURNAL OF NEUROCHEMISTRY 76: 1475-1484
Kobayashi, K, Nakano, H, Hayashi, M, Shimazaki, M, Fukutani, Y, Sasaki, K, Sugimori, K, Koshino, Y (2003) Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease. JOURNAL OF THE NEUROLOGICAL SCIENCES 208: 17-24
Kohn, KW, Pommier, Y (2005) Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 331: 816-827
Kolasa, K and Harrell, LE (2000) Apoptotic protein expression and activation of caspases is changed following cholinergic denervation and hippocampal sympathetic ingrowth in rat hippocampus. NEUROSCIENCE 101: 541-546
Kroemer, G (1997) The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nature Medicine 3: 614-620
Kuperstein, F, Yavin, E (2003)
Pro-apoptotic signaling in neuronal cells following iron and amyloid beta
peptide neurotoxicity. JOURNAL OF NEUROCHEMISTRY 86: 114-125
Leist M and Jäättelä, M (2001) Four Deaths And A Funeral: From Caspases To Alternative Mechanisms. Nature Reviews Molecular Cell Biology 2, 589 -598
Lithgow, T, Vandriel, R, Bertram, Jf and Strasser, A (1994) The protein product of the oncogene bcl-2 is a component of the nuclear-envelope, the endoplasmic reticulum, and the outer mitochondrial-membrane. Cell Growth & Differentiation 5: 411-417
Liu, DX and Greene, LA (2001) Neuronal apoptosis at the G1/S cell cycle checkpoint. CELL AND TISSUE RESEARCH 305: 217-228
Lu, DC, Soriano, S, Bredesen, DE, Koo, EH (2003)
Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein
toxicity. JOURNAL OF NEUROCHEMISTRY 87: 733-741
Luetjens, CM, Lankiewicz, S, Bui, NT, Krohn, AJ, Poppe, M and Prehn, JHM (2001) Up-regulation of Bcl-xL in response to subtoxic beta-amyloid: Role in neuronal resistance against apoptotic and oxidative injury. NEUROSCIENCE 102: 139-150
Malchiodi-Albedi, F, Domenici, MR, Paradisi, S, Bernardo, A, Ajmone-Cat, MA and Minghetti, L (2001) Astrocytes contribute to neuronal impairment in beta A toxicity increasing apoptosis in rat hippocampal neurons. GLIA 34: 68-72
Marques, CA, Keil, U, Bonert, A, Steiner, B, Haass, C,
Muller, WE, Eckert, A (2003) Neurotoxic mechanisms caused by the Alzheimer's
disease-linked Swedish amyloid precursor protein mutation - Oxidative stress,
caspases, and the JNK pathway. JOURNAL OF BIOLOGICAL CHEMISTRY 278: 28294-28302
Martin, LJ (2001) Neuronal cell death in nervous system development, disease, and injury (Review) INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 7: 455-478
Martin, LJ, Price, AC, McClendon, KB, Al-Abdulla, NA, Subramaniam, JR, Wong, PC, Liu, ZP (2003) Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins. JOURNAL OF NEUROCHEMISTRY 85: 234-247
Martin, S and Vallette, FM (2000) Apoptosis and pathologies of the central nervous system. NEUROCHIRURGIE 46: 370-375
Mattson, MP (2000) Apoptosis in neurodegenerative disorders. NATURE REVIEWS MOLECULAR CELL BIOLOGY 1: 120-129
Mattson, MP and Klapper, W (2001) Emerging roles for telomerase in neuronal development and apoptosis. JOURNAL OF NEUROSCIENCE RESEARCH 63: 1-9
Mattson, MP, Liu, D (2003)
Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity
and neuronal cell death. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
304: 539-549
Mbebi, C, See, V, Mercken, L, Pradier, L, Muller, U, Loeffler, JP (2002) Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway. JOURNAL OF BIOLOGICAL CHEMISTRY 277: 20979-20990
McPhie, DL, Coopersmith, R, Hines-Peralta, A, Chen, YZ,
Ivins, KJ, Manly, SP, Kozlowski, MR, Neve, KA, Neve, RL (2003)
DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease
mutants of the amyloid precursor protein are mediated by the p21 activated
kinase PAK3. JOURNAL OF NEUROSCIENCE 23: 6914-6927
McPhie, DL, Golde, T, Eckman, CB, Yager, D, Brant, JB, Neve, RL (2001) beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations. MOLECULAR BRAIN RESEARCH 97: 103-113
Meda, C, Vegeto, E, Pollio, G, Ciana, P, Patrone, C, Pellicciari, C and Maggi, A (2000) Oestrogen prevention of neural cell death correlates with decreased expression of mRNA for the pro-apoptotic protein Nip-2. JOURNAL OF NEUROENDOCRINOLOGY 12: 1051-1059
Melino, G (2004) P73, the "assistant" guardian of the genome? APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS. Annals of the New York Academy of Sciences 1010: 9-15
Michel, PP, Lambeng, N and Ruberg, M (1999) Neuropharmacologic aspects of apoptosis: Significance for neurodegenerative diseases. CLINICAL NEUROPHARMACOLOGY 22: 137-150
Min, SH, Hwang, DY, Kang, TS, Hwang, JH, Lim, CH, Lee,
SH, Lim, HJ, Seo, SJ, Sheen, YY, Paik, SG, Cho, JS, Kim, YK (2003)
Differential expression of proteins of caspases and Bcl-2 families in the brain
of mice. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 12: 181-183
Minogue, AM, Schmid, AW, Fogarty, MP, Moore, AC,
Campbell, VA, Herron, CE, Lynch, MA (2003)
Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect
of amyloid-beta on long term potentiation and cell death in hippocampus - A role
for interleukin-1 beta? JOURNAL OF BIOLOGICAL CHEMISTRY 278: 27971-27980
Moechars, D, Lorent, K and Van Leuven, F (1999) Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis. NEUROSCIENCE 91: 819-830
Mookherjee, P, Johnson, GVW (2001) Tau phosphorylation during apoptosis of human SH-SY5Y neuroblastoma cells. BRAIN RESEARCH 921: 31-43
Morishima, Y, Gotoh, Y, Zieg, J, Barrett, T, Takano, H, Flavell, R, Davis, RJ, Shirasaki, Y, Greenberg, ME (2001) beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. JOURNAL OF NEUROSCIENCE 21: 7551-7560
Motoyama, S, Kitamura, M, Saito, S, Minamiya, Y, Suzuki, H, Saito, R, Terada, K, Ogawa, J and Inaba, H (1998) Bcl-2 is located predominantly in the inner membrane and crista of mitochondria in rat liver. Biochemical and Biophysical Research Communications 249: 628-636
Nesic, O, Xu, GY, McAdoo, D, High, KW, Hulsebosch, C, Perez-Polo, R (2001) IL-1 receptor antagonist prevents apoptosis and caspase-3 activation after spinal cord injury. JOURNAL OF NEUROTRAUMA 18: 947-956
Niikura, T, Hashimoto, Y, Okamoto, T, Abe, Y, Yasukawa, T, Kawasumi, M, Hiraki, T, Kita, Y, Terashita, K, Kouyama, K and Nishimoto, I (2001) Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner. JOURNAL OF NEUROSCIENCE 21: 1902-1910
Nishimura, I, Takazaki, R, Kuwako, K, Enokido, Y,
Yoshikawa, K (2003) Upregulation and antiapoptotic role of endogenous
Alzheimer amyloid precursor protein in dorsal root ganglion neurons.
EXPERIMENTAL CELL RESEARCH 286: 241-251
Nishimura, I, Uetsuki, T, Kuwako, K, Hara, T, Kawakami, T, Aimoto, S, Yoshikawa, K (2002) Cell death induced by a caspase-cleaved transmembrane fragment of the Alzheimer amyloid precursor protein. CELL DEATH AND DIFFERENTIATION 9: 199-208
Nouspikel, T, Hanawalt, PC (2003) When parsimony backfires: neglecting DNA repair may doom neurons in Alzheimer's disease. BIOESSAYS 25: 168-173
Nuydens, R, de Jong, M, Van Den Kieboom, G, Heers, C, Dispersyn, G, Cornelissen, F, Nuyens, R, Borgers, M and Geerts, H (1998) Okadaic acid-induced apoptosis in neuronal cells: Evidence for an abortive mitotic attempt. JOURNAL OF NEUROCHEMISTRY 70: 1124-1133
Nuydens, R, Dispersyn, G, Van Den Kieboom, G, de Jong, M, Connors, R, Ramaekers, F, Borgers, M and Geerts, H (2000a) Bcl-2 protects neuronal cells against taxol-induced apoptosis by inducing multi-nucleation. APOPTOSIS 5: 335-343
Nuydens, R, Dispersyn, G, Van den Kieboom, G, de Jong, M, Connors, R, Ramaekers, F, Borgers, M and Geerts, H (2000b) Bcl-2 protects against apoptosis-related microtubule alterations in neuronal cells. APOPTOSIS 5: 43-51
Offen, D, Elkon, H and Melamed, E (2000) Apoptosis as a general cell death pathway in neurodegenerative diseases. JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT 58: 153-166
Onuki, R, Bando, Y, Suyama, E, Katayama, T, Kawasaki, H, Baba, T, Tohyama, M, Taira, K (2004) An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. EMBO JOURNAL 23: 959-968
Overmyer, M, Kraszpulski, M, Helisalmi, S, Soininen, H and Alafuzoff, I (2000) DNA fragmentation, gliosis and histological hallmarks of Alzheimer's disease. ACTA NEUROPATHOLOGICA 100: 681-687
Patzke, H, Tsai, LH (2002) Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. JOURNAL OF BIOLOGICAL CHEMISTRY 277: 8054-8060
Pompl, PN, Yemul, S, Xiang, ZM, Ho, L, Haroutunian, V, Purohit, D, Mohs, R, Pasinetti, GM (2003) Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. ARCHIVES OF NEUROLOGY 60: 369-376
Proteau, A, Blier, S, Albert, AL, Lavoie, SB, Traish, AM, Vincent, M (2005) The multifunctional nuclear protein p54(nrb) is multiphosphorylated in mitosis and interacts with the mitotic regulator Pin1. JOURNAL OF MOLECULAR BIOLOGY 346: 1163-1172
Raina, AK, Hochman, A, Ickes, H, Zhu, XW, Ogawa, O,
Cash, AD, Shimohama, S, Perry, G, Smith, MA (2003)
Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out?
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 27: 251-254
Raina, AK, Hochman, A, Zhu, XW, Rottkamp, CA, Nunomura, A, Siedlak, SL, Boux, H, Castellani, RJ, Perry, G and Smith, MA (2001) Abortive apoptosis in Alzheimer's disease. ACTA NEUROPATHOLOGICA 101: 305-310
Raina, AK, Zhu, XW, Shimohama, S, Perry, G, Smith, MA (2003) Tipping the apoptotic balance in Alzheimer's disease - The abortosis concept. CELL BIOCHEMISTRY AND BIOPHYSICS 39: 249-255
Rensink, AAM, Gellekink, H, Otte-Holler, I, ten Donkelaar, HJ, de Waal, RMW, Verbeek, MM, Kremer, B (2002) Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease. ACTA NEUROPATHOLOGICA 104: 525-533
Riedout, HJ and Stefanis, L (2001) Caspase inhibition: a potential therapeutic strategy in neurological diseases. HISTOLOGY AND HISTOPATHOLOGY 16: 895-908
Rissman,
RA, Poon, WW, Blurton-Jones, M, Oddo, S, Torp, R, Vitek, MP, LaFerla, FM, Rohn,
TT, Cotman, CW (2004) Caspase-cleavage
of tau is an early event in Alzheimer disease tangle pathology. JOURNAL OF
CLINICAL INVESTIGATION 114: 121-130
Rohn, TT, Head, E, Nesse, WH, Cotman, CW, Cribbs, DH (2001) Activation of caspase-8 in the Alzheimer's disease brain. NEUROBIOLOGY OF DISEASE 8: 1006-1016
Rohn, TT, Head, E, Su, JH, Anderson, AJ, Bahr, BA, Cotman, CW and Cribbs, DH (2001) Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. AMERICAN JOURNAL OF PATHOLOGY 158: 189-198
Rohn, TT, Rissman, RA, Davis, MC, Kim, YE, Cotman, CW,
Head, E (2002) Caspase-9 activation and caspase cleavage of tau in the
Alzheimer's disease brain
Rosenmann, H, Meiner, Z, Kahana, E, Aladjem, Z, Friedman, G, Ben-Yehuda, A, Grenader, T, Wertman, E, Abramsky, O (2003) An association study of the codon 72 polymorphism in the pro-apoptotic gene p53 and Alzheimer's disease. NEUROSCIENCE LETTERS 340: 29-32
Roth, KA (2001) Caspases, apoptosis, and Alzheimer disease: Causation, correlation, and confusion. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 60: 829-838
Rutten, BPF, Korr, H, Steinbusch, HWM, Schmitz, C
(2003) The aging brain: less neurons could be better. MECHANISMS OF AGEING AND
DEVELOPMENT 124: 349-355
Ruvolo PP, Deng X and May WS (2001) Phosphorylation of Bcl2 and regulation of apoptosis. Leukemia 15: 515-22
Schendel SL, Xie ZH, Montal MO, Matsuyama S, Montal M, Reed JC (1997) Channel formation by antiapoptotic protein Bcl-2. Proceedings of The National Academy of Sciences of the United States Of America 94: 5113-5118
Schinzel, A, Kaufmann, T, Schuler, M, Martinalbo, J, Grubb, D, Borner, C (2004) Conformational control of Bax localization and apoptotic activity by Pro168. JOURNAL OF CELL BIOLOGY 164: 1021-1032
Schutte, B, Nuydens, R, Geerts, H and Ramaekers, F (1998) Annexin V binding assay as a tool to measure apoptosis in differentiated neuronal cells. JOURNAL OF NEUROSCIENCE METHODS 86: 63-69
Sennvik, K, Benedikz, E, Fastbom, J, Sundstrom, E, Winblad, B and Ankarcrona, M (2001) Calcium ionophore A23187 specifically decreases the secretion of beta-secretase cleaved amyloid precursor protein during apoptosis in primary rat cortical cultures. JOURNAL OF NEUROSCIENCE RESEARCH 63: 429-437
Seo, JH, Rah, JC, Choi, SH, Shin, JK, Min, K, Kim, HS, Park, CH, Kim, S, Kim, EM, Lee, SH, Lee, S, Suh, SW, Suh, YH (2002) alpha-Synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway. FASEB JOURNAL 16: U115-U135
Shelton, SB, Johnson, GVW (2001) Tau and HMW tau phosphorylation and compartmentalization in apoptotic neuronal PC12 cells. JOURNAL OF NEUROSCIENCE RESEARCH 66: 203-213
Shimizu S, Eguchi Y, Kamiike W, Itoh Y, Hasegawa J, Yamabe K, Otsuki Y, Matsuda H, Tsujimoto Y (1996) Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-X(L). Cancer Research 56: 2161-2166
Siao, CJ, Tsirka, SE (2002) Extracellular proteases and neuronal
cell death. CELLULAR AND MOLECULAR BIOLOGY 48: 151-161
Smyth, PG, Berman, SA, Bursztajn, S (2002) Markers of apoptosis: Methods for elucidating the mechanism of apoptotic cell death from the nervous system. BIOTECHNIQUES 32: 648-659
Stoltzner, SE, Berchtold, NC, Cotman, CW, Pike, CJ (2001) Estrogen regulates bcl-x expression in rat hippocampus. NEUROREPORT 12: 2797-2800
Stoothoff, WH and Johnson, GVW (2001) Hyperosmotic stress-induced apoptosis and tau phosphorylation in human neuroblastoma cells. JOURNAL OF NEUROSCIENCE RESEARCH 65: 573-582
Su, JH, Anderson, AJ, Cribbs, DH, Tu, C, Tong, LQ,
Kesslack, P, Cotman, CW (2003) Fas and Fas Ligand are associated with neuritic
degeneration in the AD brain and participate in beta-amyloid-induced neuronal
death. NEUROBIOLOGY OF DISEASE 12: 182-193
Su, JH, Kesslak, JP, Head, E, Cotman, CW (2002) Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. ACTA NEUROPATHOLOGICA 104: 1-6
Su, JH, Zhao, M, Anderson, AJ, Srinivasan, A and Cotman, CW (2001) Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology. BRAIN RESEARCH 898: 350-357
Sun, J, Li, MT, Han, JH, Gu, J (2001) Sensitization of differentiated PC12 cells to apoptosis by presenilin-2 is mediated by p38. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 287: 536-541
Suo, ZM, Wu, M, Citron, BA, Palazzo, RE, Festoff, BW
(2003) Rapid tau aggregation and delayed hippocampal neuronal death induced by
persistent thrombin signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 278: 37681-37689
Takuma, H. Tomiyama, T, Kuida, K, Mori, H (2004) Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 63: 255-261
Takuma, K, Baba, A, Matsuda, T (2004) Astrocyte apoptosis: implications for neuroprotection. PROGRESS IN NEUROBIOLOGY 72: 111-127
Tamagno, E, Robino, G, Obbili, A, Bardini, P, Aragno,
M, Parola, M, Danni, O (2003) H2O2 and 4-hydroxynonenal mediate amyloid
beta-induced neuronal apoptosis by activating JNKs and p38(MAPK). EXPERIMENTAL
NEUROLOGY 180: 144-155
Troy, CM, Rabacchi, SA, Xu, ZH, Maroney, AC, Connors, TJ, Shelanski, ML and Greene, LA (2001) beta-amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. JOURNAL OF NEUROCHEMISTRY 77: 157-164
Weishaupt, JH, Neusch, C, Bahr, M (2003)
Cyclin-dependent kinase 5 (CDK5) and neuronal cell death. CELL AND TISSUE
RESEARCH 312: 1-8
White, AR, Guirguis, R, Brazier, MW, Jobling, MF, Hill, AF, Beyreuther, K, Barrow, CJ, Masters, CL, Collins, SJ and Cappai, R (2001) Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons. NEUROBIOLOGY OF DISEASE 8: 299-316
Wilson, C, Henry, S, Smith, MA, Bowser, R (2004) The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer disease brain. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 30: 19-29
Wolvetang, EJ, Bradfield, OM, Hatzistavrou, T, Crack, PJ, Busciglio, J, Kola, I, Hertzog, PJ (2003) Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. NEUROBIOLOGY OF DISEASE 14: 349-356
Wolvetang, EJ, Wilson, TJ, Sanij, E, Busciglio, J, Hatzistavrou, T, Seth, A, Hertzog, PJ, Kola, I (2003) ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway. HUMAN MOLECULAR GENETICS 12: 247-255
Wu, Q, Combs, C, Cannady, SB, Geldmacher, DS and Herrup, K (2000) Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons. NEUROBIOLOGY OF AGING 21: 797-806
Wulf, GM, Liou, YC, Ryo, A, Lee, SW, Lu, KP (2002)
Role of Pin1 in the regulation of p53 stability and p21
transactivation, and cell cycle checkpoints in response to DNA damage
Xu, J, Chen, SW, Ku, G, Ahmed, SH, Xu, JM, Chen, H and Hsu, CY (2001) Amyloid beta peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 21: 702-710
Xu, XM, Shi, YC, Gao, W, Mao, GZ, Zhao, GJ, Agrawal, S,
Chisolm, GM, Sui, DX, Cui, MZ (2002) The novel presenilin-1-associated protein is a
proapoptotic mitochondrial protein
Yamamoto K, Ichijo H And Korsmeyer SJ (1999) Bcl-2 is phosphorylated and inactivated by an ask1/jun n-terminal protein kinase pathway normally activated at G(2)/M. Molecular and Cellular Biology 19: 8469-8478
Yang, L, He, HY, Zhang, XJ (2002) Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. NEUROSCIENCE RESEARCH 42: 261-268
Yang, Y, Geldmacher, DS and Herrup, K (2001) DNA replication precedes neuronal cell death in Alzheimer's disease. JOURNAL OF NEUROSCIENCE 21: 2661-2668
Yang, Y, Mufson, EJ, Herrup, K (2003) Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. JOURNAL OF NEUROSCIENCE 23: 2557-2563
Yang, YL, Li, CCH, Weissman, AM (2004) Regulating the p53 system through ubiquitination. ONCOGENE 23: 2096-2106
Yao, ZX, Drieu, K and Papadopoulos, V (2001) The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands. BRAIN RESEARCH 889: 181-190
Yi, FH, Lautrette, C, Vermot-Desroches, C, Bordessoule, D, Couratier, P, Wijdenes, J, Preud'homme, JL and Jauberteau, MO (2000) In vitro induction of neuronal apoptosis by anti-Fas antibody-containing sera from amyotrophic lateral sclerosis patients. JOURNAL OF NEUROIMMUNOLOGY 109: 211-220
Yuan, JY and Yankner, BA (2000) Apoptosis in the nervous system. NATURE 407: 802-809
Zemlyak, I, Furman, S, Brenneman, DE and Gozes, I (2000) A Novel peptide prevents death in enriched neuronal cultures. REGULATORY PEPTIDES 96: 39-43
Zhang, JW and Johnson, GVW (2000) Tau protein is hyperphosphorylated in a site-specific manner in apoptotic neuronal PC12 cells. JOURNAL OF NEUROCHEMISTRY 75: 2346-2357
Zhang, Y, McLaughlin, R, Goodyer, C, LeBlanc, A (2002) Selective cytotoxicity of intracellular amyloid beta peptide(1-42) through p53 and Bax in cultured primary human neurons. JOURNAL OF CELL BIOLOGY 156: 519-529
Zhang, YH, Li, J, Zhou, ZL (2003)
Caspase-3: a new target for neurodegenerative diseases treatment. PROGRESS IN
BIOCHEMISTRY AND BIOPHYSICS 30: 175-179
Zhao, M, Su, J, Head, E, Cotman, CW (2003) Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. NEUROBIOLOGY OF DISEASE 14: 391-403
Zheng, YL, Kesavapany, S, Gravell, M, Hamilton, RS, Schubert, M, Amin, N, Albers, W, Grant, P, Pant, HC (2005) A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons. EMBO JOURNAL 24: 209-220
Zhou, Y, Zhang, WJ, Easton, R, Ray, JW, Lampe, P, Jiang, ZH, Brunkan, AL, Goate, A, Johnson, EM, Wu, JY (2002) Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG. NEUROBIOLOGY OF DISEASE 9: 126-138