| Home
Pin1 Protein
Our Research
Our TEM Research
Our Publications
Research Team
Alzheimer's Disease
Tauopathies
About this Site
Literature: A-K ; L-Z
; subject area
Search Site by Subject Area
Disclaimer/
Feedback
Links
Compiled by: Julian
Thorpe
| |
Alzheimer's disease: General

Alzheimer's Disease (AD) is the most common
cause of dementia in the elderly population (some 5-10% of people
over 65 evidence some of the signs of AD) and the fourth leading cause of
death in adults (source:
NCBI
, Bethesda, U.S.A.).
 | This neurodegenerative disease results in a slow but progressive
deterioration in cognitive ability. In its earliest stages, the symptoms
may be minor (some confusion and forgetfulness) but in later stages they
may impact enormously on the sufferer's ability to lead a normal life.
|
 | It is characterised histopathologically by the presence of
two hallmark brain lesions, extracellular deposits of
beta-amyloid
in neuritic plaques and intracellular neurofibrillary
tangles (NFTs).
|
 | In the future, as life expectancies increase and there is a
steadily increasing proportion of older people in the population, the numbers
of people affected by AD (and other such disorders) is likely to increase
dramatically. This will not only affect the lives of those of us unfortunate
enough to be sufferers; it will also create a significant burden on the
health and caring resources of communities worldwide.
|
 | There is thus a pressing need for a cure or effective
treatment for this disease and many groups of researchers throughout the world
are working on AD as you read this.
|
 | This site is an attempt to pull together some of their research
findings, especially in regard to cell biological and biochemical aspects. |
Back to Top

|