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Compiled by: Julian Thorpe

Literature L - Z

Ladu MJ; Reardon C; Van Eldik L; Fagan AM; Bu G; Holtzman D; Getz GS. (2000) Lipoproteins in the central nervous system. Ann N Y Acad Sci, 2000 Apr, 903:, 167-75

Lafay-Chebassier, C, Paccalin, M, Page, G, Barc-Pain, S, Perault-Pochat, MC, Gil, R, Pradier, L, Hugon, J (2005) mTOR/p70S6k signalling alteration by A beta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease. JOURNAL OF NEUROCHEMISTRY 94: 215-225

LaFerla, F. M.; Tinkle, B. T.; Bieberich, C. J.; Haudenschild, C. C.; Jay, G. (1995) The Alzheimer's A-beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nature Genet. 9: 21-30, 1995.

Lah, JJ and Levey, AI (2000) Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments. MOLECULAR AND CELLULAR NEUROSCIENCE 16: 111-126

Lahiri, DK, Farlow, MR, Hintz, N, Utsuki, T and Greig, NH (2000) Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease. ACTA NEUROLOGICA SCANDINAVICA 102: 60-67

Lambourne, SL, Sellers, LA, Bush, TG, Choudhury, SK, Ernson, PC, Suh, YH, Wilkinson, LS (2005) Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: Evidence for distinct molecular processes underlying tau abnormalities. MOLECULAR AND CELLULAR BIOLOGY 25: 278-293

Landrieu I, DeVeylder L, Fruchart JS, Odaert B, Casteels P, Portetelle D, VanMontagu M, Inze D, Lippens G (2000) The Arabidopsis thaliana PIN1At gene encodes a single-domain phosphorylation-dependent peptidyl prolyl cis/trans isomerase. Journal of Biological Chemistry 275: 10577- 10581

Landrieu, I, Odaert, B, Wieruszeski, JM, Drobecq, H, Rousselot-Pailley, P, Inze, D and Lippens, G (2001) p13(SUC1) and the WW domain of PIN1 bind to the same phosphothreonine-proline epitope. JOURNAL OF BIOLOGICAL CHEMISTRY 276: 1434-1438

Landrieu, I, Wieruszeski, JM, Odaert, B, Inze, D, Grzesiek, S and Lippens, G (2000) Sequence-specific H-1, C-13 and N-15 chemical shift backbone NMR assignment and secondary structure of the Arabidopsis thaliana PIN1At protein. JOURNAL OF BIOMOLECULAR NMR 17: 271-272

Landrieu, I, Wieruszeski, JM, Wintjens, R, Inze, D, Lippens, G (2002)
Solution structure of the single-domain prolyl cis/trans isomerase PIN1At from Arabidopsis thaliana. JOURNAL OF MOLECULAR BIOLOGY 320: 321-332

Lane, HA and Nigg, EA (1997) Cell-cycle control: POLO-like kinases join the outer circle. TRENDS IN CELL BIOLOGY 7: 63-68

Lane, RM, Farlow, MR (2005) Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease. JOURNAL OF LIPID RESEARCH 46: 949-968

Lau, KF, Howlett, DR,  Kesavapany, S, Standen, CL, Dingwall, C, McLoughlin, DM, Miller, CCJ (2002) Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability. MOLECULAR AND CELLULAR NEUROSCIENCE 20: 13-20

Lau KF, Miller CCJ, Anderton BH and Shaw PC (1999) Expression analysis of glycogen synthase kinase-3 in human  tissues. JOURNAL OF PEPTIDE RESEARCH 54: 85-91

Lau, LF, Ahlijanian, MK (2003) Role of cdk5 in the pathogenesis of Alzheimer's disease. NEUROSIGNALS 12: 209-214

Lau, LF, Seymour, PA, Sanner, MA, Schachter, JB (2002) Cdk5 as a drug target for the treatment of Alzheimer's disease . JOURNAL OF MOLECULAR NEUROSCIENCE 19: 267-273  

Lauckner, J, Frey, P, Geula, C (2003) Comparative distribution of tau phosphorylated at Ser(262) in  pre-tangles and tangles. NEUROBIOLOGY OF AGING 24: 767-776

Lauderback, CM, Kanski, J, Hackett, JM, Maeda, N, Kindy, MS, Butterfield, DA (2002) Apolipoprotein E modulates Alzheimer's A beta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner. BRAIN RESEARCH 924: 90-97

Lavoie SB, Albert AL, Handa H, Vincent M, Bensaude O (2001) The Peptidyl-prolyl Isomerase Pin1 Interacts with hSpt5 Phosphorylated by Cdk9. Journal of Molecular Biology 312: 675-685

Lavoie, SB, Albert, AL, Vincent, M (2003) Unexpected roles of the peptidyl-prolyl cis/trans isomerase Pin1. M S-MEDECINE SCIENCES 19: 1251-1258

Law, A, Gauthier, S and Quirion, R (2001) Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type. BRAIN RESEARCH REVIEWS 35: 73-96

Layfield, R (2001) Does an inhibition of the uhiquitin/26S proteasome pathway of protein degradation underlie the pathogenesis of non-familial Alzheimer's disease? MEDICAL HYPOTHESES 56: 395-399

Layfield, R, Cavey, JR, Lowe, J (2003) Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders. AGEING RESEARCH REVIEWS 2: 343-356

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Leclerc, S, Garnier, M, Hoessel, R, Marko, D, Bibb, JA, Snyder, GL, Greengard, P, Biernat, J, Wu, YZ, Mandelkow, EM, Eisenbrand, G and Meijer, L (2001) Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/P25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease - A property common to most cycline-dependent kinase inhibitors? JOURNAL OF BIOLOGICAL CHEMISTRY 276: 251-260

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Lee, CWC, Lau, KF, Miller, CCJ, Shaw, PC (2003) Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines. NEUROREPORT 14: 257-260  

Lee, G, Thangavel, R, Sharma, VM, Litersky, JM, Bhaskar, K, Fang, SM, Do, LH, Andreadis, A, Van Hoesen, G, Ksiezak-Reding, H (2004) Phosphorylation of tau by fyn: Implications for Alzheimer's disease. JOURNAL OF NEUROSCIENCE 24: 2304-2312  

Lee, HG, Casadesus, G, Zhu, XW, Joseph, JA, Perry, G, Smith, MA (2004) Perspectives on the amyloid-beta cascade hypothesis. JOURNAL OF ALZHEIMERS DISEASE 6: 137-145

Lee, JH, Hong, HN, Im, JO, Byun, HS and Kim, D (2000) The formation of PHF-1 and SMI-31 positive dystrophic neurites in rat hippocampus following acute injection of okadaic acid. NEUROSCIENCE LETTERS 282: 49-52

Lee, JI, Dhakal, BK, Lee, J, Bandyopadhyay, J, Jeong, SY, Eom, SH, Kim, DH, Ahnn, J (2003) The Caenorhabditis elegans homologue of down syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphatase calcineurin. JOURNAL OF MOLECULAR BIOLOGY 328: 147-156

Lee, KF, Chan, JYC, Lau, KF, Lee, WC, Miller, CCJ, Anderton, BH and Shaw, PC (2000) Molecular cloning and expression analysis of human glycogen synthase kinase-3 alpha promoter. MOLECULAR BRAIN RESEARCH 84: 150-157

Lee, KY, Clark, AW, Rosales, JL, Chapman, K, Fung, T and Johnston, RN (1999) Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain. NEUROSCIENCE RESEARCH 34: 21-29

Lee, KW, Lee, SH, Kim, H, Song, JS, Yang, SD, Paik, SG, Han, PL (2004) Progressive cognitive impairment and anxiety induction in the absence of plaque deposition in C57BL/6 inbred mice expressing transgenic amyloid precursor protein. JOURNAL OF NEUROSCIENCE RESEARCH 76: 572-580

Lee, MS, Kao, SC, Lemere, CA, Xia, WM, Tseng, HC, Zhou, Y, Neve, R, Ahlijanian, MK, Tsai, LH (2003) APP processing is regulated by cytoplasmic phosphorylation. JOURNAL OF CELL BIOLOGY 163: 83-95

Lee, MS, Kwon, YT, Li, MW, Peng, JM, Friedlander, RM and Tsai, LH (2000) Neurotoxicity induces cleavage of p35 to p25 by calpain. NATURE 405: 360-364

Lee, SS, Kim, YM, Junn, E, Lee, G, Park, KH, Tanaka, M, Ronchetti, RD, Quezado, MM, Mouradian, MM (2003) Cell cycle aberrations by alpha-synuclein over-expression and cyclin B immunoreactivity in Lewy bodies. NEUROBIOLOGY OF AGING 24: 687-696

Lee VM, Otvos L Jr, Carden MJ, Hollosi M, Dietzschold B, Lazzarini RA. (1988a) Identification of the major multiphosphorylation site in mammalian neurofilaments. Proc Natl Acad Sci U S A,1988a Mar

Lee VM, Otvos L Jr, Schmidt ML, Trojanowski JQ. (1988b) Alzheimer disease tangles share immunological similarities with  multiphosphorylation repeats in the two large neurofilament proteins. Proc Natl Acad Sci U S A, 1988b Oct, 85:19, 7384-8

Lee VM-Y, Balin BJ, Otvos LJ, Tojanowski JQ (1991) A68 - a major subunit of paired helical filaments and derivatized forms of normal-tau. Science 251: 675-678

Lee, VMY, Giasson, BI, Trojanowski, JQ (2004) More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. TRENDS IN NEUROSCIENCES 27: 129-134

Lee, VMY, Goedert, M and Trojanowski, JQ (2001) Neurodegenerative tauopathies. ANNUAL REVIEW OF NEUROSCIENCE 24: 1121-1159

Lee, VMY, Kenyon, TK, Trojanowski, JQ (2005) Transgenic animal models of tauopathies. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1739: 251-259

Lee, VMY, Trojanowski, JQ (2001) Transgenic mouse models of tauopathies: Prospects for animal models of Pick's disease. NEUROLOGY 56: S26-S30

Lefebvre, T, Guinez, C, Dehennaut, V, Beseme-Dekeyser, O, Morelle, W, Michalski, JC (2005) Does O-GlcNAc play a role in neurogenerative diseases? EXPERT REVIEW OF PROTEOMICS 2: 265-275

Lehman, EJH, Kulnane, LS, Gao, Y, Petriello, MC, Pimpis, KM, Younkin, L, Dolios, G, Wang, R, Younkin, SG, Lamb, BT (2003) Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. HUMAN MOLECULAR GENETICS 12: 2949-2956

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Leissring, MA, Farris, W, Chang, AY, Walsh, DM, Wu, XN, Sun, XY, Frosch, MP, Selkoe, DJ (2003) Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. NEURON 40: 1087-1093

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Lemere, CA, Spooner, ET, Leverone, JF, Mori, C, Iglesias, M, Bloom, JK, Seabrook, TJ (2003) Amyloid-beta immunization in Alzheimer's disease transgenic mouse models and wildtype mice. NEUROCHEMICAL RESEARCH 28: 1017-1027

Leost, M, Schultz, C, Link, A, Wu, YZ, Biernat, J, Mandelkow, EM, Bibb, JA, Snyder, GL, Greengard, P, Zaharevitz, DW, Gussio, R, Senderowicz, AM, Sausville, EA, Kunick, C and Meijer, L (2000) Paullones are potent inhibitors of glycogen synthase kinase-3 beta and cyclin-dependent kinase 5/p25. EUROPEAN JOURNAL OF BIOCHEMISTRY 267: 5983-5994

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Leroy, K, Boutajangout, A, Richardson, J, Octave, JN, Lovestone, S, Anderton, BH, Brion, JP (2003) Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth. NEUROSCIENCE LETTERS 353: 226--230

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Lewis, HD, Revuelta, BIP, Nadin, A, Neduvelil, JG, Harrison, T, Pollack, SJ, Shearman, MS (2003) Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between notch S3 and beta-APP cleavages. BIOCHEMISTRY 42: 7580-7586

Lewis, J, Dickson, DW, Lin, WL, Chisholm, L, Corral, A, Jones, G, Yen, SH, Sahara, N, Skipper, L, Yager, D, Eckman, C, Hardy, J, Hutton, M and McGowan, E (2001) Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. SCIENCE 293: 1487-1491

Lewis, J, McGowan, E, Rockwood, J, Melrose, H, Nacharaju, P, Van Slegtenhorst, M, Gwinn-Hardy, K, Murphy, MP, Baker, M, Yu, X, Duff, K, Hardy, J, Corral, A, Lin, WL, Yen, SH, Dickson, DW, Davies, P and Hutton, M (2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. NATURE GENETICS 25: 402-405

Lewis, PA, Perez-Tur, J, Golde, TE and Hardy, J (2000) The presenilin 1 C92S mutation increases A beta 42 production. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 277: 261-263

Li, BL, Ryder, J, Su, Y, Moore, SA, Liu, F, Solenberg, P, Brune, K, Fox, N, Ni, BH, Liu, RG, Zhou, Y (2004) Overexpression of GSK3 beta(S9A) resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3 beta transgenic mice. TRANSGENIC RESEARCH 13: 385-396

Li, GB, Yin, HS, Kuret, J (2004) Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. JOURNAL OF BIOLOGICAL CHEMISTRY 279: 15938-15945

Li, JL, Gould, TD, Yuan, PX, Manji, HK, Chen, G (2003) Post-mortem interval effects on the phosphorylation of signaling proteins. NEUROPSYCHOPHARMACOLOGY 28: 1017-1025  

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Li, L, von Bergen, M, Mandelkow, EM, Mandelkow, E (2002)  Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis . JOURNAL OF BIOLOGICAL CHEMISTRY 277: 41390-41400  

Li QM, Tep C, Yune TY, Zhou XZ, Uchida T, Lu KP, Yoon SO (2007) Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury. J Neurosci. 27: 8395-404

Li, T, Ma, GJ, Cai, HB, Price, DL, Wong, PC (2003) Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals. JOURNAL OF NEUROSCIENCE 23: 3272-3277  

Li, X, An, WL, Alafuzoff, I, Soininen, H, Winblad, B, Pei, JJ (2004) Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain. NEUROREPORT 15: 2237-2240

Li, YK, Liu, L, Barger, SW, Griffin, WST (2003) Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway. JOURNAL OF NEUROSCIENCE 23: 1605-1611

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Lian, QY, Ladner, CJ, Magnuson, D and Lee, JM (2001) Selective changes of calcineurin (protein phosphatase 2B) activity in Alzheimer's disease cerebral cortex. EXPERIMENTAL NEUROLOGY 167: 158-165

Liazoghli, D, Perreault, S, Micheva, KD, Desjardins, M, Leclerc, N (2005) Fragmentation of the Golgi apparatus induced by the overexpression of wild-type and mutant human tau forms in neurons. AMERICAN JOURNAL OF PATHOLOGY 166: 1499-1514

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Liu, DX and Greene, LA (2001) Neuronal apoptosis at the G1/S cell cycle checkpoint. CELL AND TISSUE RESEARCH 305: 217-228

Liu, F, Iqbal, K, Grundke-Iqbal, I, Rossie, S, Gong, CX (2005) Dephosphorylation of tau by protein phosphatase 5 – Impairment in Alzheimer's disease. JOURNAL OF BIOLOGICAL CHEMISTRY 280: 1790-1796

Liu, F, Su, Y, Li, BL, Zhou, Y, Ryder, J, Gonzalez-DeWhitt, P, May, PC, Ni, BH (2003) Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5. FEBS LETTERS 547: 193-196

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Liu, F, Zaidi, T, Iqbal, K, Grundke-Iqbal, I, Merkle, RK, Gong, CX (2002) Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease. FEBS LETTERS 512: 101-106

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