Literature: A-K ; L-Z ; subject area
Compiled by: Julian Thorpe
Microtubule-Affinity Regulating Kinase (MARK)
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Please Note: Due to time constraints, the text part of this page has not been updated for some time. However, references are added reasonably frequently. |
MARK is a non-proline directed kinase that has been implicated in PHF-tau phosphorylation by Chin et al., 2000). They used fluorescence resonance energy transfer to show a close association of this kinase with the phosphorylated serine 262 on PHF-tau and suggested that it might - to some extent - phosphorylate already-assembled PHF filaments.
Some Related References
(These journals include: Neurology, Neurobiology of Disease, Journal of Neurochemistry, Alzheimer's Disease Review)
Chin, JY, Knowles, RB, Schneider, A, Drewes, G, Mandelkow, EM and Hyman, BT (2000) Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in Alzheimer brain: A fluorescence resonance energy transfer study. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 59: 966-971
Drewes, G (2004) MARKing tau for tangles and toxicity. TRENDS IN BIOCHEMICAL SCIENCES 29: 548-555
Mandelkow, EM, Thies, E, Trinczek, B, Biernat, J, Mandelkow, E (2004) MARK/PAR1 kinase is a regulator of microtubuledependent transport in axons. JOURNAL OF CELL BIOLOGY 167: 99-110
Trinczek, B, Brajenovic, M, Ebneth, A, Drewes, G (2004) MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. JOURNAL OF BIOLOGICAL CHEMISTRY 279: 5915-5923
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