Literature: A-K ; L-Z ; subject area
Compiled by: Julian Thorpe
Neuronal cdc2-like kinase
|
Please Note: Due to time constraints, the text part of this page has not been updated for some time. However, references are added reasonably frequently. |
 | Lew and Wang (1995)reported that neurofilament proteins and the neuron-specific microtubule-associated protein tau are phosphorylated in vivo at sites conforming to the phosphorylation consensus motif of the cell-cycle-control protein kinase, p34cdc2-cyclin. Abnormalities in the phosphorylation of these proteins are associated with neurodegenerative disorders, such as amylotrophic lateral sclerosis and Alzheimer's disease. A cdc2-like kinase composed of cyclin-dependent kinase 5 (cdk5) and a brain-specific regulatory subunit is proposed to be responsible for the cdc2-like phosphorylation of these neuronal proteins. |
| Liu et al. (1995) found a Cdc2-related kinase in human brains, which was slightly smaller than p34(Cdc2) in molecular mass (approximately 33 kd). It was associated with NFT s and PHF of AD. On the basis of its physical association with NFTs these authors suggested that this 33-kd Cdc2-related kinase might play a role in producing the PHF-Tau characteristic of AD. |
| With regard to kinase inhibitors, Borgne and Meijer (1999) anticipate the discovery of novel selective and powerful ( kinase ) inhibitors which may be of therapeutic value in AD. |
| Lee et al. (1999) examined neuronal Cdc2-like kinase activity in prefrontal and cerebellar cortex from AD and control subjects (corrected either for Cdk5 level or neuronal loss). The ratio of neuronal Cdc2-like kinase activity in prefrontal versus cerebellar cortex was then compared. The ratios were higher in AD than the controls, a finding consistent with a role for neuronal Cdc2-like kinase in the pathogenesis of NFT in AD. |
Some Related References
Ahlijanian MK; Barrezueta NX; Williams RD; Jakowski A; Kowsz KP; McCarthy S; Coskran T; Carlo A; Seymour PA; Burkhardt JE;Nelson RB; McNeish JD (2000). Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc Natl Acad Sci USA 97: 2910-2915
Bennecib, M, Gong, CX, Grundke-Iqbal, I and Iqbal, K (2000) Role of protein phosphatase-2A and-1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. FEBS LETTERS 485: 87-93
Borgne, A and Meijer, L (2000) The search for and potential therapeutic applications of chemical inhibitors of cyclin-dependent kinases. M S-MEDECINE SCIENCES 15: 496-503
Brownlees J, Yates A, Bajaj NP, Davis D, Anderton BH, Leigh PN, Shaw CE, Miller CC (2000) Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-1b/Jun N-terminal kinase-3. J Cell Sci 113: 401-7
BUSH_ML, MIYASHIRO_JS, INGRAM_VM. (1995) ACTIVATION OF A NEUROFILAMENT KINASE, A TAU KINASE, AND A TAU PHOSPHATASE BY DECREASED ATP LEVELS IN NERVE GROWTH FACTOR-DIFFERENTIATED PC-12 CELLS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, Vol.92, No.6, pp.1861-1865
Ching YP, Qi Z and Wang JH (2000) Cloning of three novel neuronal Cdk5 activator binding proteins. Gene 242: 285-94
Cobb, M.H., Hepler, J.E., Zhen, E., Ebert, D., Cheng, M., Dang, A. and Robbins, D. (1995) Regulation and Structure of the MAP Kinases ERK1 and ERK2. pp. 78-87 In: Alzheimer's Disease: Lessons from Cell Biology. Eds. K.S. Kosik, Y. Christen and D.J. Selkoe. Springer-Verlag.
Crenshaw DG, Yang J, Means AR, Kornbluth S (1998) The mitotic peptidyl-prolyl isomerase, Pin1, interacts with Cdc25 and Plx1. EMBO J 17:1315-1327
Dranovsky, A, Vincent, I, Gregori, L, Schwarzman, A, Colflesh, D, Enghild, J, Strittmatter, W, Davies, P and Goldgaber, D (2001) Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology. NEUROBIOLOGY OF AGING 22: 517-528
Giasson_BI, Mushynski_WE. (1997) Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit. JOURNAL OF NEUROSCIENCE, 1997, Vol.17, No.24, pp.9466-9472
Gong C-X, Lidsky T, Weigel J, Zuck L, Grundke-Iqbal, I, Iqbal K (2000) Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. J Biol Chem 275: 5535-5544
He, JQ, Lau, AG, Yaffe, MB, Hall, RA (2001) Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase. JOURNAL OF BIOLOGICAL CHEMISTRY 276: 41559-41565
HOSOI_T, UCHIYAMA_M, OKUMURA_E, SAITO_T, ISHIGURO_K, UCHIDA_T, OKUYAMA_A, KISHIMOTO_T, HISANAGA_S. (1995) EVIDENCE FOR CDK5 AS A MAJOR ACTIVITY PHOSPHORYLATING TAU-PROTEIN IN PORCINE BRAIN EXTRACT. JOURNAL OF BIOCHEMISTRY, 1995, Vol.117, No.4, pp.741-749
Hugon, J., Sindou, P., Lesort, M., Couratier, P., Esclaire, F. and Yardin, C. (1995) Modifications of phosphorylated tau immunoreactivity linked to excitotoxicity in neuronal cultures. pp. 172-179 In: Alzheimer's Disease: Lessons from Cell Biology. Eds. K.S. Kosik, Y. Christen and D.J. Selkoe. Springer-Verlag.
James_ND, Davis_DR, Sindon_J, Hanger_DP, Brion_JP, Miller_CCJ, Rosenberg_MP, Anderton_BH, Propst_F. (1996) Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine threonine kinase Mos. NEUROBIOLOGY OF AGING, 1996, Vol.17, No.2, pp.235-241
Julien JP; Mushynski WE. (1998) Neurofilaments in health and disease.Prog Nucleic Acid Res Mol Biol, 1998, 61:, 1-23
Kosik KS, Ferreira A, Knowles R, Leclerc N and Greenberg SM (1995) Linking amyloid precursor protein processing and tau-related pathology in Alzheimer's disease. pp. 230-240 In: Alzheimer's Disease: Lessons from Cell Biology. Eds. K.S. Kosik, Y. Christen and D.J. Selkoe. Springer-Verlag.
Lee, KY, Clark, AW, Rosales, JL, Chapman, K, Fung, T and Johnston, RN (1999) Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain. NEUROSCIENCE RESEARCH 34: 21-29
Lew, J, Huang, QQ, QI, Z, Winkfein, RJ, Aebersold, R, Hunt, T And Wang, JH (1994) A Brain-Specific Activator Of Cyclin-Dependent Kinase-5. NATURE 371: 423-426
LEW_J, QI_Z, HUANG_QQ, PAUDEL_H, MATSUURA_I, MATSUSHITA_M, ZHU_XJ, WANG_JH. (1995) STRUCTURE, FUNCTION, AND REGULATION OF NEURONAL CDC2-LIKE PROTEIN-KINASE. NEUROBIOLOGY OF AGING, 1995, Vol.16, No.3, pp.263-268
LEW_J. and WANG_JH. (1995) NEURONAL CDC2-LIKE KINASE. TRENDS IN BIOCHEMICAL SCIENCES, 1995, Vol.20, No.1, pp.33-37
Lichtenberg-Kraag B, Mandelkow EM, Biernat J, Steiner B, Schroter C, Gustke N, Meyer HE, Mandelkow E. (1992) Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau. Proc Natl Acad Sci U S A, 1992 Jun, 89:12, 5384-8
Liu, Wk, Williams, Rt, Hall, Fl, Dickson, Dw And Yen, Sh (1995) Detection Of A Cdc2-Related Kinase Associated With Alzheimer Paired Helical Filaments. AMERICAN JOURNAL OF PATHOLOGY 146: 228-238
Mandelkow, E-M, Biernat, J., Lichtenberg-Kraag, B., Drewes, G., Wille, H., Gustke, N., Baumann, K. and Mandelkow, E. (1995) Phosphorylation of tau and its relationship with Alzheimer paired helical filaments. pp. 103-120 In: Alzheimer's Disease: Lessons from Cell Biology. Eds. K.S. Kosik, Y. Christen and D.J. Selkoe. Springer-Verlag.
Milton, NGN (2001) Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase. NEUROREPORT 12: 3839-3844
Nakamura Y; Hashimoto R; Kashiwagi Y; Aimoto S; Fukusho E; Matsumoto N; Kudo T; Takeda M (2000) Major phosphorylation site (Ser55) of neurofilament L by cyclic AMP-dependent protein kinase in rat primary neuronal culture. J Neurochem 74: 949-59
Pei, JJ, Braak, H, Gong, CX, Grundke-Iqbal, I, Iqbal,
K, Winblad, B, Cowburn, RF (2002) Up-regulation of cell division cycle (cdc) 2 kinase in
neurons with early stage Alzheimer's disease neurofibrillary degeneration
Perry_G, Roder_H, Nunomura_A, Takeda_A, Friedlich_AL, Zhu_XW, Raina_AK, Holbrook_N, Siedlak_SL, Harris_PLR, Smith_MA. (1999) Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation. NEUROREPORT, 1999, Vol.10, No.11, pp.2411-2415
QI_Z, TANG_DM, MATSUURA_I, LEE_KY, ZHU_XJ, HUANG_QQ, WANG_JH. (1995) REGULATORY PROPERTIES OF NEURONAL CDC2-LIKE KINASE. MOLECULAR AND CELLULAR BIOCHEMISTRY, 1995, Vol.149, pp.35-39
Qi, Z, Zhu, XD, Goedert, M, Fujita, DJ and Wang, JH (1998) Effect of heparin on phosphorylation site specificity of neuronal Cdc2-like kinas. FEBS LETTERS 423: 227-230
Roder, H.M., Eden, P.A. and Ingram, V.M. (1993) Brain protein kinase pk40(erk) converts tau into a PHF-like form as found in Alzheimer's disease. Biochem. Biophys. Res. Comm. 193: 639-647
RODER_HM, HOFFMAN_FJ, SCHRODER_W. (1995) PHOSPHATASE RESISTANCE OF ERK2 BRAIN KINASE PK40(ERK2). JOURNAL OF NEUROCHEMISTRY, 1995, Vol.64, No.5, pp.2203-2212
Sengupta, A, Kabat, J, Novak, M, Wu, QL, Grundke-Iqbal, I and Iqbal, K (1998) Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubule. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 357: 299-309
Sobue, K, Agarwal-Mawal, A, Li, W, Sun, W, Miura, Y and Paudel, HK (2000) Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau. JOURNAL OF BIOLOGICAL CHEMISTRY 275: 16673-16680
Tokuoka H; Saito T; Yorifuji H; Wei F; Kishimoto T; Hisanaga S (2000) Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons. J Cell Sci 113: 1059-68
Trojanowski, J.Q., Mawal-Dewan, M., Scmidt, M.L., Martin, J. and Lee, VM-Y. (1993) Localisation of the mitogen activated protein kinase ERK2 in Alzheimer's Disease neurofibrillary tangles and senile plaque neurites. Brain Research 618: 333-337
Van den Haute, C, Spittaels, K, Van Dorpe, J, Lasrado, R, Vandezande, K, Laenen, I, Geerts, H and Van Leuven, F (2001) Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice. NEUROBIOLOGY OF DISEASE 8: 32-44
Veeranna, Amin_ND, Ahn_NG, Jaffe_H, Winters_CA, Grant_P, Pant_HC. (1998) Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M. JOURNAL OF NEUROSCIENCE, 1998, Vol.18, No.11, pp.4008-4021
VEERANNA, SHETTY_KT, LINK_WT, JAFFE_H, WANG_J, PANT_HC. (1995) NEURONAL CYCLIN-DEPENDENT KINASE-5 PHOSPHORYLATION SITES IN NEUROFILAMENT PROTEIN (NF-H) ARE DEPHOSPHORYLATED BY PROTEIN PHOSPHATASE 2A. JOURNAL OF NEUROCHEMISTRY, 1995, Vol.64, No.6, pp.2681-2690
Veeranna GJ; Shetty KT; Takahashi M; Grant P; Pant HC (2000) Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain. Brain Res Mol Brain Res, 2000 76: 229-36
Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter A (1999) The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G2/M progression. J Cell Science 112: 3361-3371
Wolowiec, D and Ffrench, M (1996) Cyclin-dependent kinases: Biological functions and involvement in human pathology. M S-MEDECINE SCIENCES 12: 165-173
Zhu, XW, Rottkamp, CA, Raina, AK, Brewer, GJ, Ghanbari, HA, Boux, H and Smith, MA (2000) Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease. NEUROBIOLOGY OF AGING 21: 807-803