School of Life Sciences                                                                 

Publications

Journal Articles 

Page T, Gitcho MA, Mosaheb S, Carter D, Chakraverty S, Perry RH, Bigio EH, Gearing M, Ferrer I, Goate AM, Cairns NJ, Thorpe JR (2011) FUS immunogold labelling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS proteinopathy. Journal of Molecular Neuroscience (In Press)  

Paine S, Bedford L, Thorpe JR, Mayer RJ, Bajaj N, Sheppard PW, Lowe J, Layfield R (2009) Immunoreactivity to          Lys63-linked polyubiquitin is a feature of neurodegeneration. Neuroscience Letters 460: 205-208

Thorpe JR, Tang HHL, Atherton JM, Cairns NJ (2008) Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy. Journal of Neural Transmission 115: 1661-1671

Morris C, Thorpe J, Ambrosio L, Santin M (2006) The soybean isoflavone genistein induces differentiation of MG63 human osteosarcoma osteoblasts. Journal of Nutrition 136: 1166-1170

Hashemzadeh-Bonehi L, Phillips RG, Cairns NJ, Mosaheb S, Thorpe JR (2006) Pin1 protein associates with neuronal lipofuscin: potential consequences in age-related neurodegeneration. Experimental Neurology 199: 328-338  

Mosaheb S, Thorpe JR, Hashemzadeh-Bonehi L,Bigio EH,Gearing M, Cairns NJ (2005) Neuronal intranuclear inclusions are ultrastructurally and immunologically distinct from cytoplasmic inclusions of neuronal intermediate filament inclusion disease (NIFID). Acta Neuropathologica 110: 360-368  

Thorpe JR, Mosaheb S, Hashemzadeh-Bonehi L, Cairns NJ, Kay KE, Morley SJ, Rulten S (2004) Shortfalls in the Peptidyl-Prolyl Cis-Trans Isomerase Protein Pin1 in Neurons are Associated With Frontotemporal Dementias. Neurobiology of Disease 17: 237-249

Cairns NJ, Grossman M, Arnold SE, Burn DJ, Jaros E, Perry RH,  Duyckaerts C, Stankoff B, Pillon B, Skullerud K, Cruz-Sanchez FF, Bigio EH, Mackenzie IRA, Gearing M, Juncos JL, Glass JD, Yokoo H, Nakazato Y, Mosaheb S, Thorpe JR, Uryu K, Lee V.M.-Y, Trojanowski, JQ (2004) Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease (NIFID). Neurology 63: 1376-1384

Hashemzadeh-Bonehi L, Curtis PS, Morley SJ, Thorpe JR, Pain VM (2003) Overexpression of a conserved domain of fission yeast and mammalian translation initiation factor eIF4G causes aberrant cell morphology and results in disruption of the localization of F-actin and the organisation of microtubules. Genes to Cells 8: 163-178

THORPE JR ( 2002) The Peptidyl-Prolyl Cis-Trans Isomerase Protein Pin1: a key player in the molecular pathogenesis of Alzheimer’s disease? On-line review article: full text available

THORPE JR, MORLEY SJ, RULTEN,SL ( 2001) Utilising the Peptidyl-Prolyl Cis-Trans Isomerase Pin1 as a Probe of its Phosphorylated Target Proteins: Examples of Binding to Nuclear Proteins in a Human Kidney Cell Line and to Tau in Alzheimer’s Diseased Brain. J. Histochem. Cytochem.49: 97-108

JAYEOLA AA,THORPE JR, ADENEGAN TA (2001) Macromorphological and Micromorphological Studies of the West African Rhizophora Linn.Feddes Repertorium 112: 5-6, 337-344

JAYEOLA AA, THORPE JR (2000) A Scanning Electron Microscope Study of the Adaxial Leaf Surface of the Genus Calyptrochilum KRAENZL. (Orchidaceae) in West Africa. Feddes Repertorium 111: 315-320

PANDYA MJ, SPOONER GA, SUNDE M, THORPE JR, RODGER A, WOOLFSON DN (2000) Sticky-end assembly of a designed peptide fibre provides insight into protein fibrillogenesis. Biochemistry 39: 8728-8734

THORPE JR, RULTEN SL, KAY JE (1999) The binding of a putative and a known chaperone protein revealed by immunogold labelling transmission electron microscopy: A suggested use of chaperones as probes for the distribution of their target proteins. J. Histochem. Cytochem. 47: 1633-1640

RICHARDSON GP, FORGE A, KROS CJ, MARCOTTI W, BECKER D, WILLIAMS DS, THORPE JR, FLEMING J, BROWN SDM, STEEL, K.P. (1999) A missense mutation in myosin VIIA prevents aminoglycoside accumulation in cochlear hair cells. Annals of the New York Academy of Science 884: 110-124

RULTEN SL, THORPE JR, KAY JE (1999) Identification of Eukaryotic Parvulin Homologues: A new subfamily of Peptidyl-prolyl cis-trans isomerases. Biochemical and Biophysical Research Communications 259: 557-562

Di MATTEO MA, LOWETH AC, THOMAS S, MABLEY JG, MORGAN NG, THORPE JR, GREEN IC (1997)
Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of Langerhans and insulin secreting cell lines, but dictate cell death by different mechanisms. Apoptosis 2: 164-177

EIZIRIK DL, DELANEY CA, GREEN MHL, CUNNINGHAM JM, THORPE JR, PIPELEERS DG, HELLERSTROM C, GREEN IC (1996) Nitric oxide donors decrease the function and survival of human pancreatic islets. Mol. Cell Endocr. 118: 71-83

GILLIES MT, THORPE JR (1996) When is a spine not a spine? A new look at an old problem in the taxonomy of the Baetidae (Ephemeroptera). The Entomologist 115: 86-90

MOORE AL, WALTERS AJ, THORPE JR, FRICAUD AC, WATTS FZ (1992) Schizosaccharomyces pombe mitochondria: morphological, respiratory and protein import characteristics. Yeast 8, 923-933

THORPE JR (1992) A novel methodology for double protein A-gold immunolabelling utilizing the monovalent fragment of protein A.
Journal of Histochemistry and Cytochemistry 40: 435-441

GOLDIE-SMITH EK, THORPE JR (1991) Eggs of British meniscus midges (Diptera: Dixidae) observed by scanning electron microscopy. Freshwater Forum 1: 215-224

THORPE JR, WALLIS M (1991) Immunocytochemical and morphometric investigations of mammotrophs, somatotrophs and somatomammotrophs in sheep pituitary cell cultures. Journal of Endocrinology 129: 417-422

KHAWAJA XZ, GREEN IC, THORPE JR, BAILEY CJ (1990) Increased sensitivity to insulin-releasing and glucoregulatory  effects of  dynorphin-A1-13 and U-50488H in OB/OB versus lean mice. Diabetes 39: 1289-1297

THORPE JR, RAY KP, WALLIS M (1990) Occurrence of rare somatomammotrophs in ovine anterior pituitary tissue studied by immunogold labelling and electron microscopy. Journal of Endocrinology 124: 67-73

KHAWAJA XZ, GREEN IC, THORPE JR, TITHERADGE MA (1990) The occurrence and receptor specificity of endogenous opioid peptides within the pancreas and liver of the rat - comparison with brain. Biochemical Journal 267: 233-240

KHAWAJA XZ, THORPE JR, GREEN IC (1990) Effect of opiate receptor antagonists on insulin release in vitro. Diabetic Medicine 7: Suppl. 1, 19A

TOBIN AK, THORPE JR, HYLTON CM, RAWSTHORNE S (1989) Spatial and temporal influences on the cell-specific localisation of glycine decarboxylase in leaves of wheat (Triticum aestivum) and pea (Pisum sativum). Plant Physiology 91: 1219-1225

HARVEY DMR, THORPE JR (1986) Some observations on the effects of salinity on ion distributions and cell ultrastructure in wheat leaf mesophyll cells. Journal of Experimental Botany 37: 1-7

THORPE JR, HALL JL (1984) Chronology and elicitation of changes in peroxidase and phenylalanine ammonia lyase activities in wounded wheat leaves in response to innoculation by Botrytis cinerea. Physiological Plant Pathology 25: 363-379

HALL JL, KINNEY AJ, DYMOTT A, THORPE JR, BRUMMELL DA (1982) Localisation and properties of ATPase activity in pea stems and wheat coleoptiles. Histochemical Journal 14: 323-331

THORPE JR, HARVEY DMR (1979) Optimisation and investigation of the use of 2,2-dimethoxypropane as a dehydration agent for plant tissues in transmission electron microscopy. Journal of Ultrastructure Research 68: 186-194

POPE DG, THORPE JR, AL-AZAWWI MJ, HALL JL (1979) The effect of cytochalasin B on the rate of growth and ultrastructure of wheatcoleoptiles and maize roots. Planta 144: 373-383

BAKER DA, HALL JL, THORPE JR (1978) A study of the extrafloral nectaries of Ricinus communis. New Phytologist 81: 129-137

Book Contributions

THORPE JR (1999) The Application of LR Gold Resin for Immunogold Labelling.
Chapter 6 in Electron Microscopy Methods and Protocols. Ed. M.A. Hajibagheri. Methods in Molecular Biology Series. Humana Press Inc. USA Vol. 117 pp. 99-110

Provision of SEM/TEM images for 'Life', Eyewitness Science Series (1994) written by David Burnie; published by Dorling Kindersley

THORPE JR (1993) Dehydration Methods. In: Procedures in Electron Microscopy Ch. 3 Section III. Robards, A.W. and Wilson, A.J. (Eds.) Wiley

TOBIN AK, THORPE JR, JORDAN BR,ROGERS WJ (1992) Development and distribution of mitochondrial enzymes in leaves. Ch.82, pp.177-193 in: Molecular, Biochemical and Physiological Aspects of Plant  Respiration. Eds. Lambers, H. and Vanderplas, L.H.W. S P B Academic Publ

Thorpe JR (2005) Are Neuronal Deficits of the Cell Cycle and Tau-Regulating Protein Pin1 a Linking Contributory  Factor in Brain Ageing and Neurodegeneration? Sussex Centre for Neuroscience Seminars.  University of Sussex, June 20th., 2005

Mosaheb S, Hashemzadeh-Bonehi L, Rulten SL, Kay JE,  Thorpe JR and Cairns NJ (2005) Fine structure of intranuclear inclusions in neuronal intermediate filament inclusion disease. The 81st Annual Meeting of the American Association of Neuropathologists, Inc. Hyatt Regency Crystal City Arlington, VA June 9-12, 2005. Journal of Neuropathology and Experimental Neurology 64: 70

Hashemzadeh-Bonehi L, Mosaheb S, Cairns NJ, Rulten SL, Kay JE, Phillips RG and Thorpe JR (2005) Neuronal Shortfalls and Localisation to Lipofuscin of the Cell Cycle and Tau-Regulating Protein Pin1: A Linking Susceptibility Factor for Ageing and Neurodegeneration? Second Meeting on the Molecular Mechanisms of Neurodegeneration, Aula Magna, Universita' degli Studi di Milano, Via Festa del Perdono 7, 20122 - Milano (Italy) May 7-10, 2005  

Hashemzadeh-Bonehi L, Mosaheb S, Cairns NJ, Rulten S, Kay KE, Phillips RG, Thorpe JR (2005) Are Shortfalls in the Cell Cycle and Tau-Regulating Protein Pin1 a Susceptibility Factor for Neurodegeneration and Ageing?  Molecular Mechanisms of Neurodegeneration: a Joint Biochemical Society/Neuroscience Ireland Focused Meeting. University College, Dublin, Republic of Ireland. March 14th-16th 2005

Mosaheb S, Hashemzadeh-Bonehi L, Cairns NJ, Kay JE, Morley SJ, Rulten SL and Thorpe JR (2004) Shortfalls in the Peptidyl-Prolyl Cis-Trans Isomerase Protein Pin1 in Neurons are Associated With Frontotemporal Dementias. FTD Satellite Conference, University of Pennsylvania, July 15-16th. 2004

Cairns NJ, Grossman M, Arnold SE, Burn DJ, Jaros E, Perry RH, Duyckaerts C, Stankoff B, Skullerud K, Cruz-Sanchez FF, Bigio EH, Mackenzie IRA, Gearing M, Yokoo H, Nakazato Y, Mosaheb S,Thorpe JR, Uryu K, Lee VM-Y, Trojanowski JQ (2004) Clinical and Neuropathologic Variation in Neuronal Intermediate Filament Inclusion Disease (NIFID) 9th International Conference on Alzheimer's Disease, Frontotemporal Dementia Satellite Meeting, University of Pennsylvania July 15-16th, 2004    

Thorpe JR (2004) Intraneuronal damage responsible for Alzheimer's disease and other dementias.  'New Approaches in Dementia',  University of Brighton. October 6th. 2004  

Thorpe JR, Mosaheb S, Hashemzadeh-Bonehi L, Cairns NJ, Kay KE, Morley SJ, Rulten S (2004) Shortfalls in the Peptidyl-Prolyl Cis-Trans Isomerase Protein Pin1 in Neurons are Associated With Frontotemporal Dementias.  Brighton and Sussex Medical School Research Day June 30th. 2004  

CAIRNS NJ, JAROS E, PERRY R, BIGIO E, THORPE JR, MOSAHEB S, ZHANG B, LEE V M-Y, TROJANOWSKI JQ (2003) Phosphorylated neurofilaments form abnormal aggregates in Dementia with Neurofilament Inclusions. Program No. 875.4. Society for Neuroscience 33rd Annual Meeting, New Orleans, November 8 - 12, 2003

NEVES-PIESTUN BG, BERNSTEIN N, THORPE JR, YEO AR, FLOWERS TJ (1999)
Proceeding of Dahlia Greidinger International Symposium on Nutrient Managment under Salinity and Water Stress, February 28-March 4, 1999. Haifa, Israel.

Richardson GP, Forge A, Kros CJ, Marcotti W, Becker D, Williams DS, Thorpe J, Fleming J, Brown SDM, Steel KP (1998) A missense mutation in myosin VIIA prevents aminoglycoside accumulation in early postnatal cochlear hair cells Conference on Ototoxicity - Basic Science and Clinical Applications, JUN 18-20, 1998. OTOTOXICITY: BASIC SCIENCE AND CLINICAL APPLICATIONS , 110-124, 1999

NEVES-PIESTUN BG, BERNSTEIN N, THORPE JR, YEO AR, FLOWERS TJ (1998) Salt stress induced changes in the structure of growing maize leaf cells. Annual Congress of Botany-The Israeli Society of Botany, the International Association of Plant Tissue Culture and the International  Society of Plant Molecular Biology. Volcani Institute, Bet Dagan.  (Conference Abstract) February 1998.

Di MATTEO MA, THORPE JR, LOWETH A, MORGAN N, GREEN I (1996) Oxygen radicals impair beta-cell function leading to non-apoptotic cell death. Diabetalogia 39: S1 30 (Meeting Abstract )

DELANEY CA, EIZIRIK DL, LOWE JE, GREEN MHL, THORPE JR, PIPELEERS DG, HELLERSTROM C, GREEN IC (1995) Effects of nitric oxide on DNA damage and ultrastructure in islets of langerhans - a comparison of human and rodent. Diabetologia 38: S1 A17 (Abstract of the EASD, Dusseldorf)

GREEN IC, CUNNINGHAM JM, DELANEY CA, MABLEY JG, THORPE JR, LOWE J, GREEN MHL (1993) Nitric oxide effects on insulin secreting cells. Abstract of the Biochemical Society Meeting, Queens University Belfast (September1993)

THOMPSON KSJ, BAINES RA, RAYNE RC, THORPE JR, ALEF A, BACON JP (1993) Locust VPLI neurons contain three vasopressin-related peptides; VPLI activity reduces cyclic AMP levels in the CNS. Soc Neurosci Abstr 19: 1274

THORPE JR, ROGERS J, TOBIN AK (1990) A morphometric analysis of mesophyll cells in wheat leaves during development with special reference to mitochondria. 7th. Congress of the European Societies of Plant Physiology. Physiologia Plantarum 79: Abstract No. 420

RAWSTHORNE S, HYLTON C, THORPE JR, TOBIN A (1990) Mitochondrial heterogeneity in plant tissues.
7th. Congress of the European Societies of Plant Physiology. Physiologia Plantarum 79: Invited Lecture, Abstract No. 387

TOBIN AK, THORPE JR, DAY DA, WISKITCH JT, MOORE AL (1990) Immunogold localisation of glycine decarboxylase in isolated pea leaf mitochondria. 7th. Congress of the Federation of European Societies of Plant Physiology. Physiologia Plantarum 79: Abstract No. 414

GREEN IC, KHAWAJA X, THORPE JR, BAILEY CJ (1987) Immunocytochemical study of opioid peptides in lean and genetically-obese (Aston ob/ob) mouse islets of Langerhans. Regulatory Peptides 18: 353 (Abstract)